Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Fumarate Hydratase"”.
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Investigating pseudohypoxia in renal cells deficient in fumarate hydratase.
… in driving cancer. One of these enzymes, fumarate hydratase (FH), is found mutated in hereditary and leiomyomatosis and renal cell cancer syndrome, whereby affected cells are characterized by high subcellular accumulation of the metabolite fumarate. Fumarate has been shown to inhibit the …
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A Cancer-Specific Study On The Differentially Expressed Protein-Protein Interactions of Fumarate Hydratase
<p>Fumarate hydratase (FH) is an enzyme used in the Krebs Cycle to convert fumarate to malate, and it is controlled by the FH gene. In this paper, we will investigate its role in Uterine Corpus Endometrial Carcinoma (UCEC) and how FH-deficient cells affect tumorigenesis. It is well-established that …
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The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
… loss of the mitochondrial TCA cycle enzyme fumarate hydratase (FH) leads to Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), an aggressive form of renal cancer associated with poor clinical outcome. The loss of FH triggers the accumulation of fumarate, which induces a multi-layer …
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Inhibition of enzymes from mycobacteria using fragment-based approaches
… for two essential mycobacterial target proteins, fumarate hydratase (fumarase) from Mycobacterium tuberculosis (Mtb) and tRNA (m1G37) methyltransferase (TrmD) from Mycobacterium abscessus (Mab). With Mtb fumarase a high-throughput screening (HTS) hit was used to design a small library of fragments …
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Nutrient and Stress-Induced Mitochondrial Hyperfusion Regulates Cell Death Pathways
… of mTORC1. Additionally, we found the loss of fumarate hydratase prevented amino acid induced mitochondrial hyperfusion, which suggested that amino acid metabolism via the TCA cycle mediates the mitochondrial hyperfusion response. Furthermore, enzymatic inhibition of inosine monophosphate …
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Genetic basis of inherited kidney and related tumours
… of immunohistochemical (IHC) staining for the fumarate hydratase protein expression and the antibody detection of S-(2-succino)-cysteine (2-SC) in determining FH variant pathogenicity. A clinical pathway of investigation was proposed for individuals presenting with leiomyomatosis. IHC for 2SC …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… my findings in two clinical scenarios: in a fumarate hydratase-deficient (FHd) renal cell carcinoma (RCC) case, which is a rare but highly aggressive RCC subtype (Chapter 2.1); and in a cohort of patients with clear cell RCC (Chapter 2.2), which is the most common malignant histological …