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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Fumarate"”.
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Fumarate Inhibits TNF-α Release
… derivatives of a citric acid cycle intermediate, fumarate, as potential mediators of endotoxin-induced TNF-α release. We determined that 10µM dimethyl fumarate (DMF) significantly inhibited LPS-mediated soluble TNF-α released from the mouse monocyte cell line RAW 264.7, with no effect on cell …
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Investigating pseudohypoxia in renal cells deficient in fumarate hydratase.
… in driving cancer. One of these enzymes, fumarate hydratase (FH), is found mutated in hereditary and leiomyomatosis and renal cell cancer syndrome, whereby affected cells are characterized by high subcellular accumulation of the metabolite fumarate. Fumarate has been shown to inhibit the …
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A Cancer-Specific Study On The Differentially Expressed Protein-Protein Interactions of Fumarate Hydratase
<p>Fumarate hydratase (FH) is an enzyme used in the Krebs Cycle to convert fumarate to malate, and it is controlled by the FH gene. In this paper, we will investigate its role in Uterine Corpus Endometrial Carcinoma (UCEC) and how FH-deficient cells affect tumorigenesis. It is well-established that …
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Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
… is more likely with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide (TAF). Limited previous studies suggest potential genetic associations with TDF-associated renal toxicity. We hypothesized that polymorphisms in genes of potential relevance to tenofovir, TDF and TAF …
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The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
… loss of the mitochondrial TCA cycle enzyme fumarate hydratase (FH) leads to Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), an aggressive form of renal cancer associated with poor clinical outcome. The loss of FH triggers the accumulation of fumarate, which induces a multi-layer …
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Development of a novel combination radio- chemotherapy for glioblastoma multiforme
… treatment options are needed. Dimethyl fumarate is a clinically available immunomodulatory drug, currently used to treat multiple sclerosis.;One of the targets of dimethyl fumarate is glutathione, a potent chemo- and radio-resistance factor. We hypothesised that the use of dimethyl …
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The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… in order to find selective drug targets. Fumarate reduction has been previously identified as the primary source of ATP for C.elegans as well as many helminths in low oxygen environments, such as during host infection. Rhodoquinone (RQ) is an essential small molecule which is closely …
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DEVELOPMENT OF SYNTHETIC POLYMERS FOR BONE TISSUE ENGINEERING: ENGINEERING THE DEGRADATION RATE
… biodegradable synthetic polymers, poly (butylene fumarate) (PBF) and the copolymer poly (butylene fumarate)-co-(butylene maleate) (PBFcBM) is described. The unsaturated linear polyesters were synthesized via two synthetic routes, including an acid catalyzed transesterification reaction of …
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Development of imaging techniques to assess tumour cell death
… magnetic resonance spectroscopic imaging with ²H-fumarate and PET-CT with ¹⁸F-C2Am are investigated as methods for the early detection of tumour cell death post-treatment. Fumarate, an intermediate in the tricarboxylic acid cycle, is hydrated in the reaction catalysed by the enzyme fumarase to …
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Metabolic and molecular responses to interspecies hydrogen transfer between Ruminococcus albus and Wolinella succinogenes
… uses hydrogen as an electron acceptor for fumarate respiration. Cell growth was monitored by optical density (OD600) and quantitative polymerase chain reaction (qPCR). Metabolites were measured to observe changes caused by the interaction of the two bacteria. Lastly, RNA was extracted at …
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Lithium-based inorganic-organic framework materials
… results in the formation of Li2(L malate)1 x(fumarate)x, suggesting a new route to mixed-ligand inorganic-organic frameworks. Investigation into frameworks based on other dicarboxylate ligands produced four structurally diverse lithium-based inorganic-organic frameworks: 2-D frameworks lithium …
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Clinical, pharmacokinetic, and genetic determinants of change in serum creatinine among Southern Africans on dolutegravir based antiretroviral therapy
… trial of dolutegravir with tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide fumarate (TAF) plus emtricitabine (ADVANCE, NCT03122262). We assessed clinical, pharmacokinetic, and genetic factors associated with the change in serum creatinine from baseline to week 4 using linear …
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Characterization of Everolimus In Biodegradable PLAF/PLEOF Nanoparticle
… of Everolimus was measured from Poly (lactide-fumarate)(PLAF) and Poly (lactide-co-ethylene oxide fumarate))(PLEOF) nanoparticle. Synthesis of the 90%PLAF/10%PLEOF NPs and characterization with respect to particle size distribution, morphology, and loading efficiency and the elution of …
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Distribution of S-(2-Succinyl)Cysteine In the Tissues of Animal Models of Diabetes and Obesity
… is formed through irreversible reactions between fumarate and cysteine residues on proteins. Although 2SC is found in normal tissues, increased nutrients cause a back up of the electron transport chain (ETC) and a buildup of Krebs cycle intermediates, including fumarate. Previously, we have seen …
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Part I: Search for a correlation between molecular structure and mesogenicity. Part II: Cotton effects of α,β-unsaturated diesters
… esters displayed one Cotton effect but the fumarate and acetylenedicarboxylate esters exhibited two overlapping Cotton effects. In order to determine the origin of the observed Cotton effects, solvent dependent and variable temperature CD studies were performed. The data are best interpreted …
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
… (d4T), abacavir (ABC), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF), effectively inhibit EBV DNA replication.
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Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis.
… revealed that the frd operon (encoding for the fumarate reductase enzyme complex or FRD) was expressed at higher levels in the virulent H37Rv at earlier time points while the expression of aceE and pks2 was higher in the virulent strain throughout the course of infection. Assessment of frd …
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Nanoparticles as strengthening agents in polymer systems
… and the biodegradable polymer poly(propylene fumarate)/poly(propylene fumarate)-diacrylate (PPF/PPF-DA). For this study, composites were prepared using various functional groups including: a surfactant alumoxane to enhance nanoparticle dispersion into the polymer; an activated-alumoxane to …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… when dosed as either tenofovir disoproxil fumarate or tenofovir alafenamide in South Africans living with HIV. We found that rifampicin increases dolutegravir clearance more than twofold, leading to a reduction in its exposure. We confirmed that this interaction can be overcome with …
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Synthesis and characterization of matrix metalloproteinase sensitive hydrogels for articular cartilage engineering
… macromer, oligo(poly(ethylene glycol) fumarate), developed in our laboratory. A matrix metalloproteinase sensitive peptide was used to crosslink the macromer, allowing for enzymatic degradation of the hydrogel and providing more void space for the production and deposition of …
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