Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Fulvestrant"”.
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Zirconium-based metal-organic frameworks as drug delivery systems
… and deliver a large hydrophobic drug, fulvestrant, in breast cancer cells. NU-1000 was shown to be internalised by the human breast cancer cell line, MCF-7 cells, within 24 hours of incubation. Fulvestrant loaded NU-1000 reduced cancer cell proliferation and inhibited the expression of …
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
… mimics the effects of an aromatase inhibitor, or fulvestrant, an ER degrader. These data were used to calibrate a mathematical model based on key interactions between ER signaling and the cell cycle. We show that the calibrated model is capable of predicting the combination treatment of …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… morphine or the estrogen receptor antagonist, fulvestrant, did not prevent local ET-1 induced de-sensitization in females. Understanding the role of endothelin receptors in pain sensitization and de-sensitization is a critical first step in determining whether the ET system is a viable …
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Συστηματική ανασκόπηση της αποτελεσματικότητας και της ασφάλειας του Giredestrant στη θεραπεία του καρκίνου του μαστού - Systematic review on the efficacy and safety of Giredestrant for breast cancer therapy
… και της αποδόμησης του υποδοχέα ERα. Το fulvestrant, αν και κλινικά καθιερωμένο, περιορίζεται από την ενδομυϊκή χορήγηση και τις μη βέλτιστες φαρμακοκινητικές του ιδιότητες, γεγονός που οδήγησε στην ανάπτυξη νεότερων, από του στόματος εκλεκτικών αποικοδομητών των υποδοχέων οιστρογόνων, …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
… a (ERa) activity is inhibited by the antagonist, Fulvestrant. To gain a better understanding of the transcriptional role of DAX-1 in breast cancer, we utilized PCR arrays to analyze changes in gene expression in the presence of DAX-1. We identified several genes with roles in breast cancer, …
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Delineating the metastatic process in osteosarcoma; the role of bone cells, the cell environment and autophagy
… lung lesions clinically, whereas treatment with Fulvestrant increases OC numbers and decreases metastatic lesions. This links OC function to OS metastasis. Through an in vitro model of OS metastasis, we have found that the highly metastatic OS cell line HOS-143B contains a subset of highly …
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Estrogenic Activity of the Polybrominated Diphenyl Ether Flame Retardant Mixture DE-71
… and this was prevented by the antiestrogen fulvestrant. DE-71 co-treatment reduced the effect of estradiol in MCF-7 cells. In the OVX mouse (BALB/c) 3-day assay, DE-71 administered alone had no effect on uterine or vaginal tissues but when administered subcutaneously potentiated estradiol’s …
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Characterisation of oestrogenic properties of Isoflavones derived from Millettia griffoniana Baill.: - Molecular mode of action and tissue selectivity
… suppressed by the pure oestrogen antagonist, fulvestrant. The expression of Ki-67, proliferating cell nuclear antigen (PCNA) and cyclin D1 (CD1) mRNA used as indicator of cell proliferation in MCF-7 cells was assayed. Based on these in vitro results, Griff C was further tested in vivo. The …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… immunoprecipitation showed constitutive, fulvestrant-resistant, recruitment of ERα mutants to the Myc enhancer region, resulting in estrogen-independent Myc overexpression in mutant cells and tumors. Knockdown and overexpression experiments showed Myc is necessary and sufficient for …
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Impact of metabolic pathways on ER+ metastatic breast cancer therapy response
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Estrogen Receptor-Mediated Effects in the Gonadotropic LBetaT2 and AlphaT3-1 Cell lines
… en het pure anti-oestrogeen ICI 182,780 (fulvestrant) voor een sterke inhibitie van zowel basale celgroei als van ERα-gestuurde gentranscriptie. Dit eerder onverwachte resultaat kan verklaard worden door interacties tussen ERα en de insulin-like growth factor I (IGF-I) receptor in de αT3-1 …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… demonstrated in other antiestrogens including fulvestrant, raloxifene, bazedoxifene, idoxifene and lasofoxifene (Chapter 7).</p>