Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Frontotemporal dementia"”.
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Morphological alterations in frontotemporal dementia:
… morphology in the neurodegenerative disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more …
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Blood Biomarkers of Presymptomatic Frontotemporal Dementia
Frontotemporal dementia (FTD) is characterised by neuronal loss and pathological protein inclusions in the frontal and/or temporal lobes of the brain. The presymptomatic stage, marked by molecular changes years before symptom onset, offers a critical window for early detection, intervention, …
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The Role of Progranulin in Frontotemporal Dementia
Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease. FTD is a highly heritable disease, and one of the most common genetic causes is heterozygous loss-of-function mutations in GRN, the gene that …
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The family experience of frontotemporal dementia: a qualitative study
… (ToM) tasks with people with frontal-variant frontotemporal dementia (fvFTD). All the research identified is systematically appraised in terms of the methodology and the quality of the published reports. The evidence indicates that ToM is impaired in people with fvFTD; however more robust …
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Social-semantic knowledge and behavioural changes in frontotemporal dementia
… in the brain have been derived from semantic dementia, a subtype of frontotemporal dementia (FTD) associated with a degradation of conceptual knowledge following atrophy in the anterior temporal lobes (ATLs). Recent research in FTD has begun to focus on social-semantic knowledge, and its …
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Speech-Based Artificial Intelligence Emotion Biomarkers in Frontotemporal Dementia
Acoustic speech markers are well-characterized in Frontotemporal Dementia (FTD), a heterogeneous spectrum of progressive neurodegenerative diseases that can affect speech production and comprehension as well as higher-order cognition, behavior, and motor control. While profound apathy and deficits …
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Origin and Role of Nuclear Somatic Mutations in Frontotemporal Dementia
… have been associated with disease states. Frontotemporal Dementia (FTD) is a young-onset form of dementia displaying great heterogeneity with respect to clinical phenotype and pathology. Several genes have been implicated in FTD, but their true mutational prevalence has been poorly …
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Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
Frontotemporal dementia (FTD) is clinically and pathologically diverse, encompassing the behavioural variant FTD; non-fluent variant primary progressive aphasia; and semantic variant primary progressive aphasia. These are usually associated with either tau or TDP-43 pathology, with highly variable …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… a primary tauopathy, bvFTD (behavioral variant Frontotemporal Dementia or Pick’s disease). To establish the scientific premise, I used postmortem brain regions donated by the patients to NeuroBioBank under MTA (material transfer agreement) to demonstrate a neuropathological significance of PLD1 …
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PATHOLOGICAL IMPLICATIONS OF ANTI-GLUA3 ANTIBODIES IN FRONTOTEMPORAL DEMENTIA: FROM ANIMAL MODEL TO RESCUE STRATEGY
… antibodies in 20%–25% of patients with frontotemporal dementia (FTD), introducing novel implications for a pathogenic role of glutamate receptor autoantibodies in neurodegenerative diseases. Although previous in vitro studies showed that anti-GluA3 autoantibodies affect glutamatergic …
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Cognitive and brain markers in presymptomatic genetic behavioural variant frontotemporal dementia: a case-control study
… the MAPT genetic variant for behavioural variant frontotemporal dementia (bvFTD-MAPT), who are part of the FTDGeNZ study, with the aim of identifying early behavioural, cognitive and neural changes in gene-positive family members. Study one aimed to characterise signs of neuropsychological and …
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Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) is a spectrum of neurodegenerative diseases characterized by the progressive loss of the motoneurons (typical of ALS), and cognitive dysfunction (characteristic of FTD). Studies have previously identified biological sex as an important …
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How and why does social connectedness change in families living with the effects of behavioural variant frontotemporal dementia?
There is a paucity of research studies exploring the changes to social connectedness of people diagnosed with bvFTD and their families, from the premorbid to late stages of the condition. The purpose of this exploratory study was to establish how and why social connectedness changed for the study …
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A Comparison of the Frontal Variant of Alzheimer's Disease with Typical Alzheimer's Disease and Frontotemporal Dementia
… of the FvAD subgroup differ from those seen in frontotemporal dementias. The current proposal describes a study designed to examine neuropsychological and behavioral functioning in groups of AD, FvAD and FTD patients. It is predicted that the FvAD group will have an older age of onset and a …
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The Lived Experiences of Males within a Committed Relationship Who Are the Primary Caregivers for a Partner Diagnosed with Frontotemporal Dementia
… PRIMARY CAREGIVERS FOR A PARTNER DIAGNOSED WITH FRONTOTEMPORAL DEMENTIA</strong></p> <p><strong>By</strong></p> <p><strong>Aniela Kathryn Scanlon</strong></p> <p><strong>August 2020</strong></p> <p><strong>Dissertation supervised by Dr. David Delmonico</strong></p> <p><strong> Spouses who are …
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UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES
Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) are complex heterogeneous disorders with a strong genetic background, but the identification of a genetic cause is difficult given the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each characterised by neuroinflammation, with increasing evidence that the neuroinflammation …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
The syndromes associated with frontotemporal dementia are heterogeneous in their presentation and progression, with variable correlation between clinical phenotype and underlying proteinopathy. Single pathologies are associated with diverse clinical presentations, while the same clinical …
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Relationship of brain functional, structural and vascular patterns to cognition in ageing and dementia
… function at the presymptomatic stage of dementia? To address question 1, I investigated whether the increased reliance on maintaining functional connectivity for good cognition in old age is facilitated by structural network connectivity or independent of structural network connectivity. …
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