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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 27 for “"Frontotemporal Dementia (FTD)"”.

  1. The Role of Progranulin in Frontotemporal Dementia

    Werthmann, Gordon ChandlerUT Southwestern Medical Center2023

    Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease. FTD is a highly heritable disease, and one of the most common genetic causes is heterozygous loss-of-function mutations in GRN, the gene that …

    utswmed Repository record

  2. Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias

    Howe, Stephanie Pui-kayMassachusetts Institute of Technology2024

    … proteinopathies: Alzheimer’s Disease (AD), Frontotemporal Dementia (FTD), Lewy Body Dementia (LBD), and Vascular Contributions to Cognitive Impairment and Dementia (VCID). We utilize both single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) to perform a joint …

    mit Repository record

  3. The Lived Experiences of Males within a Committed Relationship Who Are the Primary Caregivers for a Partner Diagnosed with Frontotemporal Dementia

    Scanlon, Aniela2020

    … PRIMARY CAREGIVERS FOR A PARTNER DIAGNOSED WITH FRONTOTEMPORAL DEMENTIA</strong></p> <p><strong>By</strong></p> <p><strong>Aniela Kathryn Scanlon</strong></p> <p><strong>August 2020</strong></p> <p><strong>Dissertation supervised by Dr. David Delmonico</strong></p> <p><strong> Spouses who are …

    duquesne Repository record

  4. Speech-Based Artificial Intelligence Emotion Biomarkers in Frontotemporal Dementia

    Parllaku, FjonaMassachusetts Institute of Technology2022

    Acoustic speech markers are well-characterized in Frontotemporal Dementia (FTD), a heterogeneous spectrum of progressive neurodegenerative diseases that can affect speech production and comprehension as well as higher-order cognition, behavior, and motor control. While profound apathy and deficits …

    mit Repository record

  5. Investigating Diffusion Tensor Imaging Correlates of Cognitive Impairment In Idiopathic Normal Pressure Hydrocephalus and Alzheimer'S Disease

    Hasan, Omar, <p>0000-0002-3451-3299</p>2021

    … diseases such as Alzheimer’s disease (AD) or frontotemporal dementia (FTD). Clinically, it can be difficult to tell whether the pathophysiological changes leading to cognitive impairment also led to the ventriculomegaly, as may occur in AD, versus whether the hydrocephalus itself is driving …

    uthsc Repository record

  6. Morphological alterations in frontotemporal dementia:

    Santillo, AlexanderClinical Memory Research Unit, Lund University2014

    … morphology in the neurodegenerative disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more …

    lund Repository record

  7. Investigating the Effects of C9orf72 Haploinsufficiency on TDP-43 Pathology in ALS

    Lin, Lilian Tsai Wei2023

    In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), transactive response DNA-binding protein 43 (TDP-43), a mainly nuclear DNA/RNA binding protein, is mislocalized to the cytoplasm of diseased neurons, where it forms abnormally phosphorylated and ubiquitinated inclusions, …

    toronto-retro Repository record

  8. AI-Based Speech Assessment of Cognitive Impairment Disorders

    Haulcy, R'maniMassachusetts Institute of Technology2023

    … to detect cognitive impairment in patients with dementia and other neurodegenerative diseases. These diseases produce cognitive deficits that lead to changes in the acoustic and linguistic content of the speech produced by the patients. In this thesis, we analyze the speech of subjects with …

    mit Repository record

  9. UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES

    SORRENTINO, FEDERICAUniversità degli Studi di Milano2023

    Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) are complex heterogeneous disorders with a strong genetic background, but the identification of a genetic cause is difficult given the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence …

    milano Repository record

  10. Blood Biomarkers of Presymptomatic Frontotemporal Dementia

    Velzian, LydiaResearchSpace@Auckland2026

    Frontotemporal dementia (FTD) is characterised by neuronal loss and pathological protein inclusions in the frontal and/or temporal lobes of the brain. The presymptomatic stage, marked by molecular changes years before symptom onset, offers a critical window for early detection, intervention, …

    auckland-ms Repository record

  11. Identification and characterization of a pathological TDP-43 variant in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

    Chiang, Helen Yu-Shan2015

    … of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) cases. One key feature of pathological TDP-43 is the presence of lower molecular weight (MW) C-terminal species of 25 and 35 kDa, the origins of which were unclear. In investigating the mechanism(s) which …

    toronto-retro Repository record

  12. A Study of alpha-Synuclein, Parkin and TDP-43 ; Proteins Implicated in Neurodegenerative Disease.

    Foulds, PenelopeLancaster University2008

    … have shown that about 55% of patients with frontotemporal lobar degeneration (FTLD) and 25% of patients with Alzheimer's disease (AD) harbour TDP-43 immunoreactive pathological changes in their brains. Again, ELISAs were developed to investigate whether TDP-43 was present, or indeed …

    lancaster Repository record

  13. PATHOLOGICAL IMPLICATIONS OF ANTI-GLUA3 ANTIBODIES IN FRONTOTEMPORAL DEMENTIA: FROM ANIMAL MODEL TO RESCUE STRATEGY

    ITALIA, MARIAUniversità degli Studi di Milano2024

    … antibodies in 20%–25% of patients with frontotemporal dementia (FTD), introducing novel implications for a pathogenic role of glutamate receptor autoantibodies in neurodegenerative diseases. Although previous in vitro studies showed that anti-GluA3 autoantibodies affect glutamatergic …

    milano Repository record

  14. Molecular mechanisms of axonal transport impairment in C9orf72-associated neurodegenerative disease

    Young, FlorenceUniversity of Cambridge2021

    … Alzheimer’s disease, and certain forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS or motor neuron disease). However, the cellular mechanisms that lead to impaired transport in these diseases are poorly understood. In this work I focus on the most common …

    cambridge Repository record

  15. Investigating the role of mitochondrial Ca2+ in in vivo models of neurodegenerative diseases

    Twyning, MadeleineUniversity of Cambridge2024

    … disease (PD), Alzheimer’s disease (AD), Frontotemporal dementia (FTD) and Huntington’s disease (HD) represent a significant and growing burden on society and healthcare worldwide. This challenge is exacerbated by the limited understanding of the underlying causes and pathological …

    cambridge Repository record

  16. Understanding mechanisms related to psychosis in Motor Neurone Disease

    Wilcox, AliciaUniversity of Cambridge2020

    … of the syndromes of motor neurone disease (MND), frontotemporal dementia (FTD) and their overlap (FTD-MND). Clinically evident psychosis is not common, except in those with C9orf72+ expansions. However, subthreshold psychosis or pre-psychosis processes are common and provide the opportunity to …

    cambridge Repository record

  17. Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration

    Kwa, Jing EugeneUniversity of Cambridge2023

    … genetic and histopathological overlap with frontotemporal dementia (FTD) suggests extra-motor involvement, and that pathology likely extends to other neuronal populations (Chapter 1). This may be especially evident in patients with the hexanucleotide repeat expansion in the gene C9ORF72 …

    cambridge Repository record

  18. THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS

    CASAROTTO, ELENAUniversità degli Studi di Milano2023

    Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD) are two neurodegenerative diseases characterized by the presence within neurons of toxic cytoplasmic inclusions containing the insoluble forms of the TAR DNA-binding protein of 43 KDa (TDP-43) and its C-terminal fragments (CTFs) …

    milano Repository record

  19. INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.

    SMEELE, PAULIEN HERMINEUniversità degli Studi di Milano2024

    … Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases, share overlapping clinical manifestations, pathogenic mechanisms, and genetic risk factors. Notably, a hexanucleotide repeat expansion of G4C2 in the non-coding region of the …

    milano Repository record

  20. Social-semantic knowledge and behavioural changes in frontotemporal dementia

    Rouse, MatthewUniversity of Cambridge2023

    … in the brain have been derived from semantic dementia, a subtype of frontotemporal dementia (FTD) associated with a degradation of conceptual knowledge following atrophy in the anterior temporal lobes (ATLs). Recent research in FTD has begun to focus on social-semantic knowledge, and its …

    cambridge Repository record

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