Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Frontotemporal"”.
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Morphological alterations in frontotemporal dementia:
… morphology in the neurodegenerative disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more …
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Blood Biomarkers of Presymptomatic Frontotemporal Dementia
Frontotemporal dementia (FTD) is characterised by neuronal loss and pathological protein inclusions in the frontal and/or temporal lobes of the brain. The presymptomatic stage, marked by molecular changes years before symptom onset, offers a critical window for early detection, intervention, …
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The Role of Progranulin in Frontotemporal Dementia
Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease. FTD is a highly heritable disease, and one of the most common genetic causes is heterozygous loss-of-function mutations in GRN, the gene that …
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Apathy and Impulsivity in Frontotemporal Lobar Degeneration
Apathy and Impulsivity in Frontotemporal Lobar Degeneration Ian Coyle-Gilchrist Frontotemporal Lobar Degeneration (FTLD) is pathologically heterogeneous group of degenerative diseases of the brain. While there are distinct and highly recognisable clinical syndromes associated with FTLD there is …
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Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes
… pathological and genetic fractionation of frontotemporal lobar degeneration syndromes in recent years, driving the development of novel diagnostic criteria. However, phenotypic boundaries are not always distinct and syndromes converge with disease progression, limiting the insights …
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The family experience of frontotemporal dementia: a qualitative study
… (ToM) tasks with people with frontal-variant frontotemporal dementia (fvFTD). All the research identified is systematically appraised in terms of the methodology and the quality of the published reports. The evidence indicates that ToM is impaired in people with fvFTD; however more robust …
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Social-semantic knowledge and behavioural changes in frontotemporal dementia
… derived from semantic dementia, a subtype of frontotemporal dementia (FTD) associated with a degradation of conceptual knowledge following atrophy in the anterior temporal lobes (ATLs). Recent research in FTD has begun to focus on social-semantic knowledge, and its relationship to the known …
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Speech-Based Artificial Intelligence Emotion Biomarkers in Frontotemporal Dementia
Acoustic speech markers are well-characterized in Frontotemporal Dementia (FTD), a heterogeneous spectrum of progressive neurodegenerative diseases that can affect speech production and comprehension as well as higher-order cognition, behavior, and motor control. While profound apathy and deficits …
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The Cognitive and Neural Basis for Apathy in Frontotemporal Degeneration
… is especially prevalent in behavioral variant frontotemporal degeneration (bvFTD). In a sample of 20 apathetic adults with bvFTD and 17 normal controls (NC), impairments in three components of GDB--initiation, planning and motivation--were examined using a novel computerized reaction time test. …
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Behavioural disinhibition in the syndromes associated with frontotemporal lobar degeneration
The different clinical syndromes caused by frontotemporal lobar degeneration (FTLD) have highly heterogenous and overlapping features which complicate clinical and research practice. Behavioural impairments are associated with all FTLD syndromes, cause high morbidity and lack proven symptomatic …
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Origin and Role of Nuclear Somatic Mutations in Frontotemporal Dementia
… have been associated with disease states. Frontotemporal Dementia (FTD) is a young-onset form of dementia displaying great heterogeneity with respect to clinical phenotype and pathology. Several genes have been implicated in FTD, but their true mutational prevalence has been poorly …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
The syndromes associated with frontotemporal dementia are heterogeneous in their presentation and progression, with variable correlation between clinical phenotype and underlying proteinopathy. Single pathologies are associated with diverse clinical presentations, while the same clinical …
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Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
Frontotemporal dementia (FTD) is clinically and pathologically diverse, encompassing the behavioural variant FTD; non-fluent variant primary progressive aphasia; and semantic variant primary progressive aphasia. These are usually associated with either tau or TDP-43 pathology, with highly variable …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… a primary tauopathy, bvFTD (behavioral variant Frontotemporal Dementia or Pick’s disease). To establish the scientific premise, I used postmortem brain regions donated by the patients to NeuroBioBank under MTA (material transfer agreement) to demonstrate a neuropathological significance of PLD1 …
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Cognitive and brain markers in presymptomatic genetic behavioural variant frontotemporal dementia: a case-control study
… the MAPT genetic variant for behavioural variant frontotemporal dementia (bvFTD-MAPT), who are part of the FTDGeNZ study, with the aim of identifying early behavioural, cognitive and neural changes in gene-positive family members. Study one aimed to characterise signs of neuropsychological and …
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PATHOLOGICAL IMPLICATIONS OF ANTI-GLUA3 ANTIBODIES IN FRONTOTEMPORAL DEMENTIA: FROM ANIMAL MODEL TO RESCUE STRATEGY
… antibodies in 20%–25% of patients with frontotemporal dementia (FTD), introducing novel implications for a pathogenic role of glutamate receptor autoantibodies in neurodegenerative diseases. Although previous in vitro studies showed that anti-GluA3 autoantibodies affect glutamatergic …
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Identification and characterization of a pathological TDP-43 variant in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
… of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) cases. One key feature of pathological TDP-43 is the presence of lower molecular weight (MW) C-terminal species of 25 and 35 kDa, the origins of which were unclear. In investigating the mechanism(s) which …
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Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) is a spectrum of neurodegenerative diseases characterized by the progressive loss of the motoneurons (typical of ALS), and cognitive dysfunction (characteristic of FTD). Studies have previously identified biological sex as an important …
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