Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Freund's adjuvant"”.
-
The Treatment of Solid Tumours with Complete Freund's Adjuvant
… of a novel potential cancer treatment, Complete Freund’s Adjuvant (CFA), which is injected intratumourally in an attempt to induce an anti-tumour immune response, leading to tumour regression. CFA has been used in research for decades, primarily to produce research antibodies. CFA is composed of …
-
The Treatment of Solid Tumours with Complete Freund's Adjuvant
… of a novel potential cancer treatment, Complete Freund’s Adjuvant (CFA), which is injected intratumourally in an attempt to induce an anti-tumour immune response, leading to tumour regression. CFA has been used in research for decades, primarily to produce research antibodies. CFA is composed of …
-
The Interaction of Pain and Morphine on Analgesia, Locomotion, and Cognitive Functioning
… the pain state of the animals after complete Freund's adjuvant injection and morphine treatment. Whereas pain had little effect on spatial memory, morphine had profound detrimental effects that persisted beyond the analgesic effectiveness of the drug. However, morphine-induced cognitive …
-
The Role of Gonadal Hormones on Opioid Receptor Protein Density in Arthritic Rats
… the opioid receptor protein levels in Complete Freund's Adjuvant (CFA)-treated arthritic and non-arthritic male and female Lewis rats. Midbrain and spinal cord tissues were collected for comparison of the μ, δ, and κ receptor protein levels in arthritic and non-arthritic animals. Male …
-
Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… was created by bilateral injections of complete Freund's adjuvant (CFA) into the joint of rats, mimicking mechanical allodynia seen in TMJ disorder. Trigeminal ganglia were dissected after 1, 3, and 5 days after CFA-treatment. NPY expression was observed in Day 1 and Day 5 tissues, with …
-
Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine
… were given an inflammatory injection of complete Freund's adjuvant (CFA) or saline as a vehicle control in the temporomandibular joint capsule. Three and four days post-CFA-injection, intraperitoneal injections of DHE, sumatriptan, or vehicle control were delivered. I found that DHE, but not …
-
Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… mechanical hypersensitivity induced by Complete Freund's Adjuvant. In addition, I assessed the analgesic properties of fenobam, [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], an anxiolytic recently identified as a selective and potent non-competitive negative …
-
Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… with renal tubular antigen (RTA) in complete Freund's adjuvant (CFA). Rats develop heavy proteinuria, a key measure of glomerular damage, and the disease is histologically identical to human MN. It has been thought that HN is mediated by antibody-based mechanisms. More recent evidence …
-
Characterization of endothelial cells of lymphatic vessels
… mice, by intraperitoneal injection of incomplete Freund's adjuvant. Different criteria have been used in order to establish the nature of the induced lesion. Morphological and histophatological studies of the tumour developed in the peritoneal cavity revealed the presence of cells at various …
-
Forced-Exercise Dependent Changes in Cellular Immunity: Effects on Experimental Autoimmune Neuritis
… three weeks, rats were immunized with complete Freund's adjuvant containing P2 peptide. Sedentary rats developed a monophasic course of EAN. In contrast, rats subjected to forced-exercise exhibited a significantly attenuated course of EAN. Near peak of disease, evoked compound muscle action …
-
Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… by peripheral immunization with Complete Freund's Adjuvant (CFA) and pertussis toxin in the absence of CNS-specific autoantigen. This response was accompanied by a transient, moderate increase in the expression level of several proinflammatory chemokine (CCL6 and CCL2), cytokine (TNF-alpha …
-
CHARACTERIZATION AND PATHOLOGICAL STUDY OF A. HYDROPHILA IN WALKING CATFISH (CLARIAS GARIEPINUS)
… or fish injected with immunostimulant, complete Freund's adjuvant (CFA). The results of this study indicated that the virulence of each isolated Aeromonas hydrophila was different from one another, even though they had the same biochemical characteristics. No specific characters could be solely …
-
Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… of maternal immune stimulation, complete Freund's adjuvant (CFA), granulocyte-macrophage colony-stimulating factor (GM-CSF), or interferon-gamma (IFN-g), were used to stimulate the maternal immune system. Approximately 50% of fetuses from hyperglycemic (>27 mM/L) dams were malformed, with …
-
Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells.
… node of mice immunized with HEL in complete Freund's adjuvant elicit a response from the citrullinated peptide specific T cell hybridomas. Examination of APC from HEL transgenic mice revealed that splenic dendritic cells, macrophages and thymic dendritic cells presented citrullinated peptides …
-
Studies on the immune response of the ovine respiratory tract to parainfluenza 3 virus
… Inactivated virus inoculated without adjuvant by either route stimulated low or undetectable serum titres and no nasal antibody. Immunity to aerosol challenge, as assessed by viral shedding from the nose and changes in post challenge antibody titres, was best conferred by intranasal …
-
Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… NOD) mice immunized with HEL in complete Freund's adjuvant: CFA) primed HEL 11-25-specific CD4+ T cells and HEL 20-35-specific CD8+ T cells; CD8+ T cell cross-priming was confirmed by several methods, including CD8+ T cell depletion, analysis of mice lacking CD8+ T cells and blockade of …
-
Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
The inoculation of a single dose of Complete Freund's Adjuvant (CFA) in Dark Agouti rats induces a polyarthritis that resembles rheumatoid arthritis (RA) in humans. The specific role of T cells in the pathogenesis of RA is controversial but a considerable body of evidence suggests that the joint …
-
Estrogen Signaling in Trigeminal Nociception
… trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain disorders. We measured withdrawal responses to stimulation of the masseter (V3, primary allodynia) and whisker …
-
Sympathetic Nerve Modulation of Joint Pathology in Adjuvant-Induced Arthritis
… Methods: Adult rats were injected with complete Freund’s adjuvant. At 12 days post immunization, animals were randomly placed into a drug treatment group (SH1293, which interacts with - and ß2-ARs), an adjuvant arthritic group, or a control group. These animals were sacrificed at 14, 21, 28 and …