Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Free heme"”.
-
A Free Heme Perspective to Sickle Hemoglobin Polymerization
… towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small molecule which has been previously shown to enhance the polymerization by orders of magnitude and removal of free heme from the supersaturated HbS solution stops the polymerization …
-
Ligand discrimination and inhibition of heme iron autooxidation by myoglobin: Site-directed mutagenesis of a synthetic gene
… pressure to overcome the natural tendency of a free heme prosthetic group to bind carbon monoxide (CO) 1000-fold more tightly than atmospheric dioxygen (O$\sb2$). Without protein-directed discrimination between these ligand molecules, the basal production of CO from various catabolic processes …
-
Supercharging: An Investigation into the Effects of External Amino Acid Residue Charge on the Solubility and Internal Electric Character of Bound Ligands in a Heme-Binding de novo-Designed Protein
… the modification of a simple, well-characterized heme-binding protein by altering side chain residue identities on the hydrophilic surface of the protein to produce variants with a range of net external charges. These charge modifications had a significant impact on nearly every measurable …
-
Establishing a Murine Model of Malaria-Associated Acute Kidney Injury and Demonstrating the Contribution of Extrinsic Apoptosis to Tubular Necrosis
… HPTEC death is not triggered by cell-free heme or hemoglobin but rather by factors unique to PfiRBC rupture. The outcomes of this study provide the field with standardized systems to study MAKI in vivo and in vitro that can be used to investigate signaling mechanisms underlying this …
-
Glutathione metabolism of Plasmodium falciparum
… in resistant parasites. GSH is able to degrade heme, the target of CQ, in vitro and it has been suggested that elevated GSH levels contribute to CQ resistance. However, analyses of isogenic parasite lines bearing different forms of PfCRT in this study revealed lower GSH levels and higher …