Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"FrbG"”.
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Structural studies of Butirosin D and FrbG
… and accompanying biochemical characterization of FrbG, which catalyzes the hydroxylation of CMP-conjugated aminopropylphosphonate. We show that FrbG is a novel enzyme that shares a similar function with known flavin-containing monooxygenases (FMOs) but is structurally distinct from these other …
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Microbial synthesis of antimalarial compound FR-900098: pathway characterization and engineering
… the FAD and NADPH dependent N-hydroxylase FrbG. A series of biochemical analyses and the solved crystal structure provided insights into the catalytic mechanism, including nucleotide conjugation as a recognition mechanism for FrbG activity. A thorough understanding of the FR-900098 …
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Directed Evolution of Phosphite Dehydrogenase and Engineered Biosynthesis of Fr-900098
… (FrbF), a novel amide hydroxylase (FrbG), and a promiscuous nucleotide hydrolase (FrbI). The presence of cytidine 5'-monophosphate (CMP) conjugated phosphonate intermediates in the pathway also gives fascinating new insights into how phosphonate antibiotic pathways evolve to protect …