Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Frazzled"”.
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Frazzled And Abelson Interact To Regulate The Actin Cytoskeleton In Drosophila
<p>Guidance receptors such as Frazzled affect cell shape and motility by directly or indirectly modulating the cytoskeleton. Fra is particularly needed for the formation of the posterior commissures in a developing Drosophila embryo. The cytoplasmic tyrosine kinase, Abelson Kinase (Abl) enhances …
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
… signaling: the intracellular domain (ICD) of Frazzled (Fra), the Drosophila ortholog of the conserved guidance receptor Deleted in Colorectal Cancer (DCC), functions as a transcription factor to control axon responsiveness to the embryonic ventral midline. In Chapter 1, I introduce the …
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
… neurons require Netrin and its DCC receptor, Frazzled, for midline axon crossing. To identify genes that function in Netrin signal transduction in vivo, we have taken two approaches: (1) a candidate gene approach to address a well-accepted model based on in vitro observation and (2) a genetic …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… the highly conserved guidance receptor DCC, or Frazzled in Drosophila, which signals chemoattraction upon binding its ligand, Netrin. DCC mutations in humans are associated with mirror movement disorder, an inability to independently control the right and left sides of the body. Although …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… of commissureless, netrin, roundabout, and frazzled during neural development. Analysis of the individual axon pathways of RP3, V, and RP2 in wildtype and commissureless and roundabout mutants investigated how abnormal midline decisions affect subsequent growth cone pathfinding. Results …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
… I present phenotypic analysis of Dscam1, Dscam1 frazzled and Dscam1 robo1 double mutants, showing that the subtle phenotypes observed in Dscam1 mutants alone are not enhanced nor suppressed by frazzled and/or robo mutations. Moreover, I aimed to model Down syndrome gut nervous system defects in …