Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1536 for “"Fragment"”.
-
An Archaeology of the Fragment: The Transition from the Antique Fragment to the Historical Fragment in French Architecture Between 1750 and 1850
… changed between the years 1750 and 1850. The fragment itself changed, as did the ways it was used. The transformation of the fragment followed three stages: it changed from the antique, to the elemental, to the historical fragment. Through the course of this transformation, design also …
-
Computational approaches to fragment based screening
… in docking. However, the growing interest in fragment - based drug design, coupled with the small size of fragments that makes them amenable to quantum mechanical treatment, has created new opportunities for including polarization, anisotropic electrostatics and realistic repulsion potentials …
-
An ionization chamber for fission fragment analysis
Fission fragments play a pivotal role in understanding the entire nuclear fission process, and their effects are widespread to all applications involving nuclear fission: reactor design and maintenance, waste removal, active and passive integration of nuclear materials, simulations, and the …
-
A Lightweight Framework for Universal Fragment Composition
… a language-inclusive solution. We build upon fragment-based composition techniques and make them applicable to arbitrary (context-free) languages. We call this process for the composition techniques’ universalization. The techniques are called fragment-based since their view of components— …
-
Theological Plunderphonics: Public Theology and "the Fragment"
… in public theology, I construct a theory of "the fragment" that enables the public theologian to respond adequately to contemporary exigencies and appropriately to traditional self-understandings. After surveying four streams of public-theological thought (chapter one), I consider the debate …
-
Fragment synthesis: pharmacophore and diversity oriented approaches
This thesis explores two approaches to fragment-based drug discovery. First, protein target CK2 was chosen due to its importance in the cancer phenotype. A literature fragment, NMR154L, proved to be a promising compound for fragment development, due to its binding at the interface site of the …
-
Machine Learning Methods for Hypervelocity Fragment Flyout Characterization
… such as collisions and explosions, hypervelocity fragments create potential hazards for both terrestrial and on-orbit environments, such as terrestrial weapons explosions and satellite breakup events, respectively. To avoid unnecessary damage, an accurate understanding or characterization of …
-
Highly Accurate Fragment Library for Protein Fold Recognition
… <p>First, we identify a protein structural fragment library (Frag-K) composed of a set of backbone fragments ranging from 4 to 20 residues as the structural “keywords” that can effectively distinguish between major protein folds. We firstly apply randomized spectral clustering and random …
-
A time-of-flight spectrometer for fission fragment identification
Fission fragment and product inventories play a key role in many areas of nuclear science from simulation of fissioning systems to diagnostics for optimal reactor operation and waste disposal. New experimental data are needed to further reduce the uncertainty in the current standard data as well as …
-
»knabenmädchenhaft«. Geschlechterschwindel in Hofmannsthals Andreas- Fragment. Eine quellenkundliche Untersuchung
La tesi dottorale ricostruisce, attraverso un’analisi delle fonti, lo sviluppo del concetto di androginia nel romanzo-frammento »Andreas« di Hugo von Hofmannsthal (1874-1929). Grazie ad una pratica di lettura onnivora e weltliterarisch, l’androginia diviene per l’autore punto di intersezione di …
-
Inhibition of enzymes from mycobacteria using fragment-based approaches
… in this thesis is focused on the application of fragment-based approaches for two essential mycobacterial target proteins, fumarate hydratase (fumarase) from Mycobacterium tuberculosis (Mtb) and tRNA (m1G37) methyltransferase (TrmD) from Mycobacterium abscessus (Mab). With Mtb fumarase a …
-
Fragment-based approaches to targeting EthR from mycobacterium tuberculosis
… elaboration of three chemical scaffolds using fragment-based approaches to develop novel inhibitors capable of disrupting the EthR-DNA interaction. The first scaffold, 5-(furan-2-yl)isoxazole was investigated by fragment-merging approaches and produced compounds with the best of these having a …
-
Application of molecular mechanics polarization to fragment based drug design.
… and electrically charged species. When studying fragments in FBDD these minor interactions could have large effect in changing how well a ligand will bind to its target. After including the polarizability terms in docking a validation set of ligands (Favia et al., 2011) with GLIDE, it improved …
-
Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… interest in utilizing truncated antibody fragments, including single-domain antibodies (sdAb), as therapeutics, as their small size affords favorable properties such as increased tumor penetration as well as the ability to utilize lower-cost prokaryotic production methods. However, they …
-
Embedded-fragment studies of ice, water, and molecular cluster cations
The embedded-fragment scheme known as the binary interaction method (BIM) was extended to enable ab initio second-order many-body perturbation (MP2) theory simulations of molecular liquids and solids with nonorthogonal lattice vectors. Three related anomalies of water ice Ih were investigated with …
-
Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
The spacer region of pRb2/p130 was reported to be able to inhibit the kinase activity of Cdk2. The region responsible for the inhibitory effect was further narrowed down to a 39-amino-acid sequence, which was named as Spa310. In this dissertation, the anti-cancer functions and mechanisms of Spa310 …
Page 1 of 77