Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Fragile X mental retardation 1"”.
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Experience-Dependent and Input-Specific Regulation of Neocortical Circuit Development by Genes Linked to Neurodevelopmental Disorders
… Specifically, patients with neurodevelopmental disorders like autism often show an imbalance in the local versus long-range connectivity for cerebral cortex. Whether and how genes implicated in neurodevelopmental disorders regulate development of cortical synaptic connectivity in a …
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Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and autism. The genetic defect in FXS is a CGG trinucleotide repeat expansion (>200) in the promoter region of the FMR1 (fragile X mental retardation 1) gene; this amplification causes the absence of the encoded …
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Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
… HPat interacts with the <em>Drosophila</em> Fragile X Mental Retardation Protein (dFMR1), to regulate neuronal structure in a <em>Drosophila melanogaster</em> fragile X model. First, we demonstrated that HPat interacts biochemically with dFMRP in an RNAse independent manner. Second, we show …