Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Fracture Healing"”.
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Pharmacological manipulation of fracture healing and bone remodeling
… technically oriented orthopedic surgery. Bone healing and physiological skeletal remodeling involve a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone at the disease or injury site. Pharmaceutical substances, both …
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Fracture healing in osteopenic bone and the influence of simvastatin
… in the ability to prevent osteoporotic fracture a vast number of mainly elderly patients continue to sustain fractures resulting in significant morbidity and a huge demand on health care services. Current knowledge of the process of fracture healing in osteoporotic bone is limited but …
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Predictive modelling of the form and development of bone fracture healing
… this study that the rate and formation of bone healing can be modelled mathematically and computationally, respectively, based on mechanical stimuli induced by the relative motion between bone fragments. To argue this case, the following hypotheses are tested; 1) the relationship between …
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FRACTURE HEALING IN A RABBIT MODEL: A STUDY OF OSTEOCALCIN LOCALISATION
… was used to localise osteocalcin during fracture healing in tissue sections of adult rabbit tibiae. A peroxidase anti-peroxidase technique and an indirect peroxidase technique were assessed on newly developing bone in human fracture callus. Three antibodies which cross-reacted with human …
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A radiographic assessment of pediatric fracture healing and time since injury
Thesis (M.S.)--Michigan State University. Department of Forensic Science, 2008
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Comparative analysis of transcriptome of fracture healing under normal and hypophosphatemic conditions
Phosphate deficiency delays bone healing by disrupting various cellular and molecular processes involved in bone regeneration. This transcriptomic analysis investigates the intricate relationship between environmental effects of phosphate deficiency on the time course of fracture healing within the …
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Fracture healing : the effects of local insulin delivery via calcium sulfate and tricalcium phosphate
… the major role played by insulin in osseous healing. This is the first study to examine local intramedullary insulin delivery to the fracture site and its effect upon the normal fracture healing process. Preceding results show that when administered at the fracture site of the impaired …
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Healing of Bone Fracture in Type 1 Diabetic Rat Models: a Potential Gene Therapy Using Bone Morphogenetic Protein
… related comorbidities, low-energy-trauma fracture is one of the major causes of morbidity and mortality of patients, due to the increased fracture risk in comparison with normal group and the impaired healing procedure after fracture. Bone morphogenetic proteins are well-known for their …
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Using HR-pQCT and finite element analysis to inform clinical assessment of distal radius fractures
Distal radius fractures (DRFs) are commonly treated non-operatively with cast immobilization; however, there are no standardized clinical practice guidelines to direct optimal duration of immobilization following a DRF. Finite element (FE) modelling coupled with high-resolution peripheral …
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… long bones are robust in small defects such as fractures but diminish in large defects due to lack of proper cellular cues. A small animal in vivo model has been developed to study the effect of two biocompatible scaffolds, an artificial polymer scaffold (HDDA) and a protein (zein) scaffold, on …
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Characterization of the microstructural properties that are predictive of regain in strength in phosphate-deficient mice
Fracture healing occurs in a discrete set of steps, which recapitulates embryonic endochondral bone formation. Pathophysiologies of the fracture healing that prolong the fracture repair or result in non-union may be associated with either environmental or congenital deficiencies. Phosphate …
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Optimization of culture conditions for equine bone marrow mesenchymal stem cells and their differentiation into osteoblasts
… animals is of great focus for horse owners. Bone fractures are an aspect of equine health failure that is continually catastrophic and often fatal. In addition to discussing fracture, this review will outline the process by which bone tissue is regularly maintained and self-healed. Also, …
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Development of an Experimental and Computational Pipeline for Characterizing the Mechanical Properties and Micromechanical Environment within In Vitro 3D Printed Bone Tissue Engineered Scaffolds
Delayed fracture healing is the improper healing of fractures within a reasonable amount of time and is estimated to impact a sixth of all fractures that occur annually in the United States1. While blood- and imaging-based bone turnover biomarkers have been thoroughly investigated throughout the …
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A clinical and biomechanical study of cast-brace treatment of fractures of the femoral shaft
This thesis reviews fracture treatment from early history to the beginning of the First World War; and treatment of fractures of the femoral shaft from then to the present day. A detailed review of the knowledge of fracture healing in relation to fractures of the femoral shaft is undertaken, with a …
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hyaluronic acid networks in wound healing
… the mechanisms underlying incomplete or abnormal healing are poorly understood. Diseases that hinder regeneration in humans often involve an abnormal accumulation of extracellular matrix (ECM)–a network of molecules occupying the space outside of cells. Beyond structural support, the ECM plays a …
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The Role of Mechanical Interactions between Cells and the Extracellular Matrix on Mineralization in a Stem Cell-Seeded Scaffold: a Multi-Scale Approach
Fracture healing is a complex phenomenon, which is not always successful, especially in elderly osteoporotic bones with a diminished capacity to bear load. Tissue engineering with stem cells may offer an approach to augment the healing rate in difficult-to-heal cases. Cell-collagen gel constructs …
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Bone growth following demineralized bone matrix implantation requires angiogenesis
… endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear. In this study, we utilize an in vivo model of endochondral ossification in mice by implanting demineralized bone matrix (DBM) …
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