Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Fractalkine"”.
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
… crosstalk mediated by CX3CR1 and fractalkine (CX3CL1; FKN) signaling provides a neuroprotective environment in several neurological diseases. FKN is a protein expressed on neuronal membranes (mFKN) and undergoes constitutive cleavage to release a soluble domain (sFKN), while the …
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Requirements for cleavage and function of the transmembrane chemokine fractalkine/CX3CL1
… cell migration an unusual member the CX3CL1 (fractalkine) is described existing as a transmembrane and a soluble molecule. The generation of this soluble CX3CL1 molecule occurs upon ectodomain shedding by metalloproteinases, in particular by ADAM10. By binding to the receptor CX3CR1 the …
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CNS endothelium expression of ADAM-17 and its role in multiple sclerosis pathogenesis.
… (TNF) and the chemokine and adhesion molecule, fractalkine, both of which have been implicated in MS pathogenesis. To determine the functional role of ADAM-17 in MS pathogenesis, an adult human brain endothelial cell line, hCMEC/D3 (a model of the BBB), was studied to determine the relationship …
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Charakterisierung des proinflammatorischen Phänotyps neointimaler glatter Gefäßmuskelzellen nach Gefäßverletzung
… was triggered by the CXC chemokine GRO-alpha and fractalkine, wheras blocking MCP-1 or the SDF-1alpha receptor CXCR4 on monocytes did not significantly affect monocyte arrest. Enhanced VLA-4 dependent memory T cell arrest, however, was reduced by blockade of CXCR4, indicating mediation by …
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Structural mechanisms of experience-dependent synaptic plasticity in the mouse visual cortex
… of proper microglial functioning via the fractalkine receptor (CX3CR1) in OD plasticity following 3 days of MD. I first identify increased lysosomal content in microglia within layer 4 (L4) of binocular visual cortex following MD, which suggests microglia participate in this structural …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… margins was expression of the neuronal chemokine Fractalkine (CX3CL1). Deficiency of the Fractalkine receptor CX3CR1 resulted in decreased CD11c+ DC recruitment. In addition, decreased CD11c+ DC recruitment was accompanied by decreased T cell recruitment, an increase in the spatial diffusion of …
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Steroid induced neuroprotection of damaged photoreceptor cells
… up-regulated photoreceptor-microglial, fractalkine-CX3CR1 signalling 1000-fold in the P20 rd10 mouse. Known to prevent microglial activation, we hypothesise that Norgestrel acts as a vital anti-inflammatory in the diseased retina, driving fractalkine-CX3CR1 signalling to delay retinal …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… 7 days after the injection. Injection of either fractalkine or CCL3 failed to enhance neurite outgrowth while both chemokines were sufficient to increase the number of macrophages in the DRGs. The differential effects are probably due to differential macrophage polarization, because CCL2 …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… abolished the synapse loss induced by gp120. Fractalkine (FKN; a.k.a.CX3C ligand-1 or CX3CL1), a microglia-activation chemokine that is specifically expressed in neurons, was up-regulated in response to gp120 stimulation. Knockout (KO) of the FKN receptor CX3CR1, which is specifically …
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The role of neuron-microglial interactions in Ataxia-Telangiectasia
… expression of growth factors, such as FGFs and fractalkine, is reduced in ATM-deficient co-cultures. The establishment of neurite patterns is crucial for the functional specification of neurons during development. Therefore, aberrant neuron-microglial interactions in ATM deficiency may result in …
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Role of monocyte subsets in chronic liver injury and liver fibrosis
… CCR2, CD64, CD62L and low levels of the fractalkine receptor CX3CR1, whereas the non-classical CD14lowCD16+ monocyte subset expresses high levels of CX3CR1 and lack CCR2. Their counterparts in mice are CCR2+Gr-1hi and CCR2-Gr-1low monocytes, respectively. Liver fibrosis is the consequence …
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The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… stimulation. The chemokines, MCP1, MIP1beta and Fractalkine were also shown to increase MMP9 secretion by rat microglia with little or no effect on MMP2. Interestingly, MCP1, MIP1alpha/beta and RANTES significantly decreased the secretion of uPA by CHME3 cells which may indicate an increase in …