Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 120 for “"Foxp3"”.
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Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
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Defining the biological role of FOXP3 in human CD4+ T cells
… role of a protein known as forkhead box P3 (FOXP3) that was initially identified as an essential transcription factor for the development of mouse CD4⁺CD25⁺ Tregs, in human CD4⁺ T cells. Following confirmation that, like mouse Tregs, human Tregs also expressed high levels of FOXP3, several …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… was to investigate the association between the FOXP3 rs2294020, ICOS rs6726035 and ICOSL rs378299 SNPs and the susceptibility to SSc or to progression from preclinical SSc to definite SSc in a North Italian Caucasian population. Furthermore, we have extended our association analysis of the FOXP3 …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… and immune homeostasis. Forkhead box P3 (Foxp3)+ Treg function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. Recently, Interleukin (IL)-4 has been shown to play an important role in determining the fate of Foxp3+ Tregs. In vivo, …
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CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
… microenvironment (TME). In this context, CD4+ FOXP3+ regulatory T cells (Tregs) have emerged as a major immunosuppressive population sustaining cancer progression. In physiological conditions they mediate immune tolerance and maintain balance in immune responses, controlling their intensity and …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA approach to silence IL-10 gene expression in murine DC10 and we generated DC10 from CD80/86 or H-2Iab gene-KO mice. When used to treat …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… receptor alpha chain (IL-4Rα). Forkhead box P3 (Foxp3⁺) Regulatory T (Treg) cells are an unique subset of CD4⁺ T cells that play important immunomodulatory roles maintaining a balance between Type 1 and Type 2 immune responses. During L. major-induced cutaneous leishmaniasis, Treg cells …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
… of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this, we combined global repertoire analyses and functional assessments of isolated T-cell receptors …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… which controls the function of Forkhead box P3 (Foxp3) regulatory T cells. This thesis addressed the hypothesis that interleukin-4 receptor alpha (IL-4Rα) signalling on T regulatory cells (T reg) play a role in the stability of T reg cells. Loss of IL-4Rα signalling on T reg cells may shift the …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
Atrazine (ATR) is a selective pre- and post-emergence herbicide widely used for agricultural purposes as well as weed control in non-crop areas. Although banned from the European Union in 2006 due to potential environmental and health risks, this common environmental toxicant is heavily used in the …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
Atrazine (ATR) is a selective pre- and post-emergence herbicide widely used for agricultural purposes as well as weed control in non-crop areas. Although banned from the European Union in 2006 due to potential environmental and health risks, this common environmental toxicant is heavily used in the …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
CD4+CD25+FoxP3+ T regulatory cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy donors. Tregs suppress tumour-specific immune …
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LNCFOXP3 CONTROLS CELL IDENTITY AND FUNCTION OF HUMAN REGULATORY T CELLS
… stability of their master transcription factor FOXP3. Given the role of lncRNAs in defining cell identity and function, we have previously shown lncRNAs specifically expressed in this lymphocyte subset. Here we present long non-coding FOXP3 (lncFOXP3), a newly identified lncRNA gene located in …
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Peripheral Generation of Regulatory T Cells in Health and Disease
CD4+CD25+FOXP3+ regulatory T cells (Tregs) form an important arm of the immune system responsible for suppressing untoward immune responses. They play a role in autoimmunity, allergy, asthma, transplantation, tumors and infectious diseases. Tregs are increased in the peripheral blood of chronic …
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
<p>Foxp3<sup>+</sup> regulatory T cells (T<sub>R</sub>) are an immunosuppressive subset of CD4<sup>+</sup> T cells that maintain homeostasis of the immune system. They are sustained by the interaction between the Major Histocompatibility Complex (MHC) molecules present on antigen presenting …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… the formation, differentiation, and activity of Foxp3+ regulatory T (Treg) cells can be affected by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. …
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HUMAN GENETIC VARIANTS IN ESSENTIAL SPLICING FACTORS AND THEIR IMPACT ON IMMUNE PATHOLOGY
… to altered splicing of Forkhead box P3 (FOXP3) – an immunoregulatory gene critical for regulatory T (Treg) cell function and homeostasis. Mutations in FOXP3 cause immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, and aberrant expression of FOXP3 has been …
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