Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Foxn1"”.
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Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
… correlates with the decline in the expression of Foxn1 in thymic stroma. Foxn1 is a transcription factor critical for functional maturation of TEC and thymic organogenesis. Mutations in Foxn1 result in the nude phenotype characterized by hairless and athymic conditions. Interestingly, nude mice …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… of the TEC master transcriptional regulator, Foxn1, as well as the expression of multiple chemokines. MiR-205 mimics introduced into miR-205 deficient fetal thymic organ cultures were able to restore the levels of Foxn1 and selected chemokines. This work demonstrates that miR-205 positively …
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… parathyroid domains can be identified by <em>Foxn1</em> and <em>Gcm2</em> expression respectively. Neural crest cells, (NCCs) play a role in regulating patterning of 3rd PP endoderm. In addition, pharyngeal endoderm influences fate determination via secretion of Sonic hedgehog (Shh), a …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… committed to the thymus lineage express <em>Foxn1 </em>whereas PT-fated cells express <em>Gcm2</em>. While these transcription factors are required for organ-specific differentiation, the exact molecular mechanisms that specify endodermal progenitors to either the thymus or parathyroid …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… that are hallmarks of thymic development, FoxN1 and Dll4, regulate Wnt-5b genetic expression in vitro. However, further work is needed to determine if Wnt-5b is affecting TEC development through canonical or non-canonical Wnt signaling and whether the modulation is due to an altering of …
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Finding the Best Gene Candidate(s) as a Potential Therapeutic Target for N-MYC Overexpressing Neuroendocrine Prostate Cancer (NEPC)
… three candidate genes (WNT1, SOX17, and FOXN1) identified from the genome-wide screen. Moreover, to suggest a more effective strategy to treat NEPC, we applied a combination of gene knockout and drug therapy. Three drugs, Chidamide, Belinostat, and Fludarabine, were tested to check cell …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… thymus and contributed to both Keratin+ and FoxN1+ TECs as well as FSP1+ thymic fibroblasts. Significantly, when Actin-H2BGFP fetal thymi were transplanted under the kidney capsule of a Rosa 26 mRFP transgenic mouse and allowed to grow for three weeks RFP-expressing CD45+EpCAM+ and …
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Análisis transcriptómico global del silenciamiento de FUCA1 en queratinocitos revela nuevos hallazgos sobre la patogenesis de las lesiones cutáneas de la fucosidosis
… de factores de transcripción como por ejemplo, FOXN1. Por lo tanto, proponemos que las lesiones cutáneas relacionadas con la fucosidosis (e.g. angioqueratoma) y las de otras enfermedades (e.g. psoriasis) pueden ser causadas por disfunciones en cascadas moleculares comunes superpuestas. Por …