Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"FoxO3a"”.
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
FOXO3a is a pro-apoptotic transcription factor which shows increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated …
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Regulatory And Functional Aspects Of Foxo3a Transcription Factor And Their Implications In Prostate Cancer
… One of the main targets of this pathway is FoxO3a, a transcription factor whose target genes are involved in important cellular processes such as apoptosis, cell cycle control, and glucose metabolism. FoxO3a is regulated by various post translational modifications including acetylation, …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… major component on redistribution of ZO-1 and FoxO3a-mediated degradation of claudin-5 during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative …
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… to that of another forkhead family member, FOXO3a. Additionally, localization of FOXO3a is known to be differentially regulated by upstream kinase AKT. Therefore, I investigated whether FOXC2 localization could also be regulated by upstream kinases. Analysis of FOXC2 protein sequence …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… to stabilization and nuclear localization of FOXO3A resulting in transcriptional activation of the cyclin-dependent kinase inhibitor P27KIP1. Also, we found that the CCN5-induced PI3K-AKT inactivation leads to stabilization and nuclear accumulation of P27KIP1 resulting in cell cycle arrest of …
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… cell metastasis in vivo, and is dependent on FOXO3a activation, demonstrate a potential role for dyslipidemia in radiation sensitivity and survival among IBC patients, reveal miR-33a regulates HDL-induced radiation sensitivity in breast cancer, and mesenchymal stem cells (MSCs) and macrophages …
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… regulate vascular differentiation, including Foxo3A and Insulin-Like Growth Factor (IGF) pathways. We explored the role of IGFs in vasculogenesis specifically and determined for the first time that IGF1 and IGF2 promote mesoderm and endothelial differentiation, mediated through HIFl[alpha] …
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Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration
… to activation of the JNK/c-jun signaling and a Foxo3a dependent transcriptional program. The cell body acts as a convergence point for these two pathways resulting in upregulation of the proapoptotic protein Puma, itself identified through a genetic knockout screen. We further show that although …
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Mitochondrial metabolism and CNS myelination
… individual myelin sheaths are, 10) in a PI3K-Akt-FoxO3a-Tfam pathway dependent way. These results provide answers to fundamental questions of oligodendrocyte biology and may have important implications for the development of future treatments. Moreover, this is the first study that demonstrates a …
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Molecular Regulation of Direct Cardiac Reprogramming
… complex 1 (mTORC1) and forkhead box o3a (Foxo3a) acted downstream of AKT1 to influence fibroblast-to-cardiomyocyte reprogramming. Addition of AGHMT converted 50% of mouse embryo fibroblasts to beating cardiomyocytes. However, only 1% of adult fibroblasts displayed spontaneous beating after …
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Susceptibilidad al cáncer colorrectal familiar no polipósico con tumores estables a microsatélites (HNPCC-X)
… en la vía Wnt (ß-catenina, c-myc, ciclina D1 y foxO3a) en tumores HNPCC-X y HNPCC-MSI. Tras el análisis inmunohistoquímico se observó una mayor activación de la vía Wnt en tumores HNPCC-X asemejándose más a la carcinogénesis de tumores colorrectales esporádicos. 3. Estudio del diplotipo Yin-Yang …