Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"FoxO1"”.
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FoxO1 in the regulation of adipocyte autophagy and biology
… metabolic stress activates transcription factor FoxO1 in obesity, my dissertation project is designed to depict the role of FoxO1 in adipocyte autophagy and biology. We found that FoxO1 upregulation was concomitant with elevation of autophagy activity during adipogenesis. Inhibition of FoxO1 …
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Sex Differences In Endothelial FoxO1 Response To Nutrient And Oxidative Stress
… Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were assessed. Male ECs …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo …
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Examining Sex Differences of Adipose Endothelial Cells and the Effects of Foxo1 Deletion
… transcription factor forkhead box O1 (FoxO1), which is more highly expressed in female ECs despite higher angiogenic activity. FoxO1 knockdown or inhibition in females led to a dysfunctional EC phenotype which was marked by inflammation, oxidative stress, impaired mitochondrial …
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DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION
… PIT1 are known to contribute to CPHD in humans. FOXO1 is a member of a large family of forkhead transcription factors. FOXO1 is expressed in various tissues where it functions to regulate metabolism, maintenance of cell differentiation, vascular development, cell cycle progression and apoptosis. …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… cells. The Forkhead box O transcription factors FOXO1 and FOXO3 (to lesser extent) are essential for naïve and memory T cell differentiation. However, FOXO1 and FOXO3 function is not restricted to quiescent T cells; there is increasing evidence for a role in differentiation of effector T cells …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… factors in mouse spermatogenesis and SSCs. Foxo1 was found to specifically mark mouse gonocytes, and its cytoplasmic-to-nuclear translocation delineated the gonocyte-to-SSC transition in neonatal testes. In adults, Foxo1 is specifically expressed within a subset of undifferentiated …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… are the transcription factors E2A, HEB, EBF1 and FOXO1 as well as the IL7 signaling cascade. The objective of this thesis has been to increase our understanding of the transcriptional network orchestrating B-lineage specification and commitment. Based on the combined expression of surface markers …
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Regulation of Energy Metabolism by Fructose in the Liver
… in liver. SREBP-1 and ChREBP, and possibly FoxO1, likely mediate gene induction by dietary fructose. The study also suggests that further ChREBP activation occurs in the nucleus after nuclear translocation of ChREBP in F-fed rat.
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Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… cells (U-2 OS) with constitutive expression of FOXO1 protein labeled with GFP (green fluorescent protein) and human hepatoma cells HepG2 cell cultures, the ability of benzylisothiocyanate (BITC) deriving from benzylglucosinolate, extracted from nasturtium to modulate, i) the insulin-signaling …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
… Similarly, partially restoring the activity of Foxo1, a downstream transcription factor negatively regulated by mTORC2 signaling, also largely rectified the defects of PTEN-deficient Treg cells. Together, these results establish that Treg cells rely on the PTEN-mTORC2-Foxo1 axis to maintain …
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Einfluss von Glucolipotoxizität auf die Funktion der β-Zellen diabetessuszeptibler und –resistenter Mausstämme
… wie durch Abnahme von phospho-AKT, phospho-FoxO1 sowie des β-zellspezifischen Transkriptionsfaktors PDX1 gezeigt wurde. Mit Ausnahme des Effekts einer Dephosphorylierung von FoxO1, konnten ob/ob-Mäuse diesen Signalweg aufrechterhalten und dadurch einen Verlust von β-Zellen abwenden. Die …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… the activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene transcription without inducing anti-inflammatory genes or activating CREB, and this pro-inflammatory skewing could be abolished by inhibition of GSK3 …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… that absence of BCAP hinders inactivation of FOXO1 and GSK3b that contributes to their enhanced inflammatory state. BCAP deficiency also results in defective aerobic glycolysis and reduced lactate production. This translates into reduced histone lactylation and decreased expression of …
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Enhancing T cell immunotherapy through dosing of memory transcription factors
… extends to other memory factors, as low-dose FOXO1 expression also augments T cell responses in an analogous manner. Thus, memory factor dosage emerges as a key regulator of T cell fate, suggesting that quantitative tuning of gene expression can drive qualitative improvements in cancer …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… (C/EBPß) and the forkhead transcription factor (FOXO1) in the activation of the PDK4 gene by T3. ERRα and FoxO1 recruit PGC-1α to the proximal PDK4 promoter and are involved in the synergistic stimulation of the PDK4 gene by T3 and PGC-1α. C/EBPß was identified as an important accessory factor in …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… maintaining B cell homeostasis will be explored. Foxo1, Foxo3, and Foxo4 have both anti-mitogenic and pro-apoptotic properties. The transcription factors are posttranslationally controlled via Akt. When a mature B lymphocyte is stimulated through the BCR, Akt-mediated phosphorylation of Foxos …
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Expression and function of basigin during early pregnancy and spermatogenesis
… forkhead transcription factor forkhead box O1A (FOXO1). In the present study, HESCs were transfected with small interfering RNAs targeting BSG gene expression. Expression of the decidualization markers Insulin-like growth factor-binding protein 1 (IGFBP1) and Prolactin (PRL) was significantly …
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Epidermal Reactions to Injury with Implications for Innate Immunity
… factor binding sites for forkhead box O1 (FOXO1), FOXO4 and STAT5A, in the most differentially expressed genes in injured skin. This indicates, for the first time, that these transcription factors might play a major role in the wound healing process.
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Lipoprotein Lipase in the Arterial Wall: Regulation by Dietary Fatty Acids
… LpL levels in response to FA. Increased arterial Foxo1 expression can contribute to decreased PPARα levels in the group fed n-3 FA. The levels of GPIHBP1 in the arterial wall correlate with arterial macrophage number. This indicates the existence of other pathways important in mediating changes …
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