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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"FoxO"”.

  1. The role of FOXO transcription factors in multiple myeloma

    Kielwein-Ulrich, JuliaUniversität Ulm

    ulm-diss Repository record

  2. FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway

    Lah, Carol Joonhyun2010

    … This proposal tests the hypothesis that FOXO, a crucial component of the InR pathway, mediates the regulation of developmental timing. The aims are the following: 1. Observe if dFOXO mutants affect temporal differentiation in the Drosophila eye. 2. Perform epistasis experiments to …

    utswmed Repository record

  3. The Role of Foxo Transcription Factors in B Cell Development and Activation

    Hinman, Rochelle Marie2011

    … ultimate B cell fate. In this thesis, the roles Foxo transcription factors play in maintaining B cell homeostasis will be explored. Foxo1, Foxo3, and Foxo4 have both anti-mitogenic and pro-apoptotic properties. The transcription factors are posttranslationally controlled via Akt. When a mature B …

    utswmed Repository record

  4. Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis

    Goertz, Meredith Johanna2013

    … here describes the discovery of a role for the Foxo forkhead transcription factors in mouse spermatogenesis and SSCs. Foxo1 was found to specifically mark mouse gonocytes, and its cytoplasmic-to-nuclear translocation delineated the gonocyte-to-SSC transition in neonatal testes. In adults, Foxo1 …

    utswmed Repository record

  5. Profile of FoxO proteins and MnSOD in two cold-hardy insect species exposed to low temperature

    Yao, LinhuiCarleton University2007

    carleton Repository record

  6. Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi

    Kennedy, Lisa Michelle2013

    … modulates the activity of the conserved DAF-16/FOXO transcription factor non-autonomously in the hypodermis to regulate HSN migration. Furthermore, I identify PAK-1, a p21-activated kinase, as a downstream target of DAF-16 in the hypodermis. This study is the first to demonstrate a …

    columbia-diss Repository record

  7. Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease

    Ikediashi Nwadozi, Emmanuel2020

    … I investigated the role of forkhead box O (FoxO) transcription factors that are potent repressors of skeletal muscle angiogenesis and have previously been implicated in the progression of metabolic disorders. In transgenic mice that have an endothelial cell directed depletion of FoxO …

    york Repository record

  8. Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB

    Bertacchini, Jessika <1980>Alma Mater Studiorum - Università di Bologna2008

    … A well described nuclear substrate if Foxo. IGF-1 triggers phosphorylation of Foxo by Akt inside the nucleus, where phospho-Foxo associates to 14.3.3 proteins that, in turn, promote its export to the cytoplasm where it is sequestered. Remarkably, Foxo phosphorylation by Akt has been …

    bologna Repository record

  9. Determining the Role of Trib3 in Neuronal Apoptosis

    Zareen, Neela2012

    … mechanism involving Akt and its substrates, the FoxO transcription factors. It is also shown that Trib3 is transcriptionally regulated by the FoxO, JNK and apoptotic cell-cycle pathways. The data further demonstrate that Trib3 functions in a feed-forward loop with the FoxOs and deactivates Akt in …

    columbia-diss Repository record

  10. Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention

    Guzman-Perez, ValentinaUniversität Potsdam

    … response to insulin. Forkhead box O (FOXO) transcription factors play a crucial role in the regulation of insulin effects on gene expression and metabolism, and alterations in FOXO function could contribute to metabolic disorders in diabetes. In this study using stably transfected …

    potsdam-diss Repository record

  11. Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation

    Ames, KristinaThe Graduate School and University Center of The City University of New York2017

    … BEC-1/BECN1 requires DAF-18/PTEN but not DAF-16/FOXO for this function and can both promote and inhibit germ cell proliferation depending on the genetic mutant background. Furthermore, ATG-18 and ATG-16.2 also act independently of the GLP-1/Notch and DAF-7/TFG-beta pathways, however it seems that …

    cuny-grad Repository record

  12. The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN

    Shen, Zhirong2011

    … by relieving transcriptional inhibition by FoxO transcription factors. ENTPD5 hydrolyzes UDP to UMP to promote protein N-glycosylation and folding in ER. Knockdown of ENTPD5 in PTEN-null cells causes ER stress and loss of receptor tyrosine kinases through ER-associated degradation pathway …

    utswmed Repository record

  13. HIF-2: Standing Guard at the Crossroads of Stress and Aging

    Dioum, El Hadji Mamadou2010

    … In lower organisms and cell culture models, the FoxO family of transcription factor regulates the transcription of SOD2 and other major AOE. During oxidative stress, Sirt1 modulates FoxO transcriptional activity, promoting the protective cellular response to oxidative stress. We hypothesized that …

    utswmed Repository record

  14. Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ

    Choi, Hyun Ho2012

    … Akt and promoting cell survival by suppressing FOXO, an Akt target, transcriptional activity. Also, CSN6 overexpression leads to increased cell growth, transformation and promotes tumorigenicity. Significantly, 14-3-3σ expression can correct the abnormalities mediated by CSN6 expression. These …

    uthsc Repository record

  15. Búsqueda de potenciales agentes quimioterápicos para los trastornos del espectro autista (TEA) utilizando Caenorhabditis elegans como modelo de estudio

    Giunti, Sebastián2024

    … sección, nos propusimos estudiar la vía PI3K/AKT/FOXO. Esta vía se encuentra altamente conservada y presenta sus respectivos homólogos en C. elegans, como daf-18 (homólogo de PTEN) y daf-16 (homólogo de FOXO, una importantísima familia de factores de transcripción), entre otros. Como un abordaje …

    uns-ar Repository record

  16. Stress-induced remodeling of the caenorhabditis elegans dauer

    Androwski, Rebecca JoannUniversity of Illinois at Urbana-Champaign2021

    … for the neuron to remodel, including the FOXO transcription factor/DAF-16, phosphatase PTEN/DAF-18 and Cytochrome P450/DAF-9. Finally, we find that the TOR associated protein, RAPTOR/DAF-15 regulates mutually exclusive branching of the IL2 and FLP dendrites. Together, our results shed …

    uiuc Repository record

  17. The nidogen-domain protein DEX-1 is necessary for the Caenorhabditis elegans dauer morphology and behavior

    Flatt, Kristen M.University of Illinois at Urbana-Champaign2020

    … during dauer is also regulated through DAF-16/FOXO-mediated transcriptional activation. Finally, we show that dex-1 genetically interacts with a family of zona pellucida-domain genes to regulate seam cell remodeling and alae formation. Taken together, this work shows that DEX-1 is an …

    uiuc Repository record

  18. Modulation of Pi3K-Akt Pathway In Colorectal Cancer

    Nusrat, Maliha, <p>https://orcid.org/0000-0002-0417-0416</p>2021

    … that AKT inhibition in metastatic CRC induces FOXO-mediated adaptive upregulation of RTKs, namely IGF1R, possibly reactivating the pathway. PI3K-altered MSS CRC is an immunologically distinct subgroup with increased immune engagement, but also checkpoint upregulation, resulting in overall …

    uthsc Repository record

  19. The ecological genetics of senescence and stress resistance in Caenorhabditis elegans

    Savory, Fiona RachelUniversity of Leeds2010

    … and spatial and temporal distributions of the FOXO transcriptions factor DAF-16, suggest that this is because age-1 mutants are more able to survive, develop and reproduce during and/or after exposure to environmental stress, due to increased expression of genes involved in somatic maintenance …

    whiterose Repository record

  20. Identifying the Role of DAP-1 and H3.3 Histones in Starvation and Longevity in <i>Caenorhabditis Elegans</i>

    Malik, YasirUniversity of Dundee2019

    … establish that the transcription factor DAF-16/FOXO which acts downstream of the Insulin-like/DAF-2 signalling pathway, also governs the expression of DAP-1 during starvation and thus facilitates organismal survival in response to starvation. Overall, we establish DAP-1 as important factor in …

    dundee Repository record

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