Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"FoxM1"”.
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Characterization of novel small molecule inhibitors of FOXM1 as potential therapeutic agents for breast cancer
… targets and therapies. Forkhead box M1 (FOXM1) is a cell cycle associated transcription factor that is remarkably overexpressed in breast cancers and has a biological role in all hallmarks of cancer development, from oncogenic transformation to treatment resistance and metastasis. …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… up-regulation of oncogenic transcription factor FOXM1, also known to be suppressed by p53. <br/><br/>HDACi are an emerging class of epigenetic modifying anti-cancer agents that we hypothesise will enhance p53 mediated cell death, whilst also altering patterns of gene expression to target …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… την πιθανή συμμετοχή του μεταγραφικού παράγοντα FoxM1 στο καρκίνωμα του πνεύμονα και την πιθανή συσχέτισή του με το μονπάτι του Hedgehog. Έγινε μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και …
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The Role of Wnt3a in Ischemic Stroke
… cell survival through the Frizzled-1/PIWI1a/FOXM1 pathway in MCAO rats. 229 Sprague-Dawley rats were assigned to male, female, and aged 9-month male MCAO or sham groups followed by reperfusion 2 hours after MCAO. Animals assigned to MCAO were either given wnt3a or its control. To explore the …
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Serologische Identifizierung von Tumorantigenen des kutanen T-Zell Lymphoms mit Fokus auf Plasmamembranproteine
… ein Ko-Aktivator des Androgen-Rezeptors; FOXM1, ein in Embryonalgewebe ubiquitär auftretender Transkriptionsfaktor; MT5-MMP, eine im Abbau von extrazellulärer Matrix involvierte Proteinase und das Adhäsionsprotein Integrin alpha 4. Western Blot Analysen zeigten, dass Ku86 bei HuT78-Zellen …
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TIS21 inhibits cell migration and invasion
… the mitochondria. Furthermore, TIS21 inhibited FoxM1 phosphorylation and downregulated MMP-2 expression. In conclusion, TIS21 inhibited cell migration and invasion by inhibition of Src by downregulation of ROS generation in mitochondria, furthermore, TIS21 inhibited FoxM1 phosphorylation and …
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Negative regulation of gene expression by the tumor suppressor p53
… of the oncogenic transcription factor FoxM1. Mechanistically, this repression is largely dependent upon the p53-inducible gene p21, and consequently involves the Rb-family of tumor suppressors. Functionally, p53-dependent repression of FoxM1 contributes to the maintenance of a stable G2 …
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
… by the cell cycle transcription factor FOXM1. The genes that scale are used in Scaling-informed Machine Learning (SIML) to better predict overall patient survival and to better identify cell lineage in single cell RNA profiles. A distinct role of Lamin A is revealed by experiments on the …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… signaling and activated the transcription factor FOXM1, a key regulator of endothelial regeneration. VT-109 enhanced endothelial proliferation, restored inter-endothelial junction integrity, and promoted resolution of vascular injury. Notably, treatment also facilitated epithelial repair by …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… disease, and the transcription factor FOXM1 was highlighted as a promising target candidate in SOX2-driven LUSC tumours. Additionally, transcriptional data of LUSC tumours was used to identify differentially expressed genes in SOX2-high tumours, and identified TrkB (encoded by the …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… multiple cell death pathways, and by suppressing FOXM1 and PCNA. Finally, we demonstrate that lignans and other investigational compounds perturb cancer cell survival through enhancing the anti-cancer effects of known clinically used anti-cancer agents such as microtubule targeted drugs and …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… (FOXO1, HAND2, IL15, IGFBP1, HOXA10, 17ßHSD2 and FOXM1). Immunohistochemistry evaluated spatiotemporal immunolocalisation, on a selection of samples, of sex steroid receptors (PR, PRB, ERα, AR) as well as Ki67, 17ßHSD2, and HOXA10 in AUB-L, AUB-A, AUB-L&A, and AUB-E samples. A randomly selected …