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Showing 1 to 13 of 13 for “"Fourier-transform mass spectrometry"”.
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Investigating Antibiotic Biosynthesis Using Quadrupole-Fourier Transform Mass Spectrometry
The following study describes the application of Q-FTMS to obtain mechanistic insight into the biosynthesis of peptide antibiotics produced either nonribosomally or by extensive post-translational modification of a ribosomally-encoded precursor.
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Uncovering the Biosynthesis of Natural Products Using Fourier-Transform Mass Spectrometry
… assembled by a vast array of enzymes which can transform the simplest building blocks into large, complex molecules. Fourier-Transform mass spectrometry (FTMS) is a powerful technique for the accurate determination of mass in complex mixtures. A large portion of this research is focused on the …
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Analyzing Post Translational Modifications on Yeast Core Histones Using Fourier Transform Mass Spectrometry
"In the end, a ""Middle-Down"" mass spectrometry approach has also been developed to study the kinetics of autoacetylation for the histone acetyltransferase, p300."
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Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides
… and data processing of MS and MS/MS data from Fourier transform ion cyclotron resonance mass spectrometers. These instruments have made great strides in the past few years, moving from labor-intensive, largely manual systems to the current flagship of the Kelleher group – a 12 tesla hybrid LTQ …
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Biosignature storage in sulfate minerals- synthetic and natural investigations of the jarosite group minerals
… elemental carbon analysis and laser-desorption Fourier transform mass spectrometry (LD-FTMS) and were found to contain the amino acid glycine. Synthetic experiments were conducted in which the different end-members were synthesized in the presence of glycine as well as the amino acid alanine and …
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Biosignature storage in sulfate minerals- synthetic and natural investigations of the jarosite group minerals
… elemental carbon analysis and laser-desorption Fourier transform mass spectrometry (LD-FTMS) and were found to contain the amino acid glycine. Synthetic experiments were conducted in which the different end-members were synthesized in the presence of glycine as well as the amino acid alanine and …
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BIO/ORGANIC COMPOUND DETECTION USING SODIUM SULFATE MINERALS: IMPLICATIONS IN THE SEARCH FOR LIFE ON MARS AND EUROPA
… Monument, Idaho was examined by laser desorption Fourier transform mass spectrometry (LD-FTMS), infrared spectroscopy and sulfur isotopic fractionation. These experiments show that bio/organic compounds are likely associated with the secondary Na-sulfate minerals, suggesting biological involvement …
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BIO/ORGANIC COMPOUND DETECTION USING SODIUM SULFATE MINERALS: IMPLICATIONS IN THE SEARCH FOR LIFE ON MARS AND EUROPA
… Monument, Idaho was examined by laser desorption Fourier transform mass spectrometry (LD-FTMS), infrared spectroscopy and sulfur isotopic fractionation. These experiments show that bio/organic compounds are likely associated with the secondary Na-sulfate minerals, suggesting biological involvement …
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Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry
… unit into the growing chain can be measured as a mass shift to the biosynthetic proteins by mass spectrometry. Specifically, Fourier-transform mass spectrometry (FTMS) (and an associated suite of custom MS tools) is a high-resolution analytical technique well suited to the study of NRPS and PKS …
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Optimization of sample preparation in Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry of macromolecules
… ionization time-of-flight (MALDI-TOF) and Fourier transform mass spectrometry (MALDI-FTMS) analysis of low molecular weight polyvinyl acetate (PVAc) was developed and then applied to the characterization of commercially available chewing gum. The optimization of MALDI analysis of PVAc was …
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Reengineering and Discovery of Nonribosomal Peptide Synthetases
… to the synthetases throughout biosynthesis. Mass spectrometry is an especially well suited tool for analyzing both the products of NRPS pathways and the machinery that produces them. A review of NRPS enzymology and contemporary mass spectrometric methods for their analysis is given in Chapter …
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Fourier Transform Based Analysis of Mass Spectra: Disentangling Mass Heterogeneity and Polydispersity
… subtle variances. Advances in soft ionization mass spectrometry (MS) methods such as electrospray ionization (ESI) and desorption electrospray ionization (DESI) have brought together solution phase separation techniques and sensitive gas phase analysis, reducing both sample concentration and …