Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Fourier-transform mass spectrometry"”.
-
Investigating Antibiotic Biosynthesis Using Quadrupole-Fourier Transform Mass Spectrometry
The following study describes the application of Q-FTMS to obtain mechanistic insight into the biosynthesis of peptide antibiotics produced either nonribosomally or by extensive post-translational modification of a ribosomally-encoded precursor.
-
Uncovering the Biosynthesis of Natural Products Using Fourier-Transform Mass Spectrometry
… assembled by a vast array of enzymes which can transform the simplest building blocks into large, complex molecules. Fourier-Transform mass spectrometry (FTMS) is a powerful technique for the accurate determination of mass in complex mixtures. A large portion of this research is focused on the …
-
Analyzing Post Translational Modifications on Yeast Core Histones Using Fourier Transform Mass Spectrometry
"In the end, a ""Middle-Down"" mass spectrometry approach has also been developed to study the kinetics of autoacetylation for the histone acetyltransferase, p300."
-
Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides
… and data processing of MS and MS/MS data from Fourier transform ion cyclotron resonance mass spectrometers. These instruments have made great strides in the past few years, moving from labor-intensive, largely manual systems to the current flagship of the Kelleher group – a 12 tesla hybrid LTQ …
-
Biosignature storage in sulfate minerals- synthetic and natural investigations of the jarosite group minerals
… elemental carbon analysis and laser-desorption Fourier transform mass spectrometry (LD-FTMS) and were found to contain the amino acid glycine. Synthetic experiments were conducted in which the different end-members were synthesized in the presence of glycine as well as the amino acid alanine and …
-
Biosignature storage in sulfate minerals- synthetic and natural investigations of the jarosite group minerals
… elemental carbon analysis and laser-desorption Fourier transform mass spectrometry (LD-FTMS) and were found to contain the amino acid glycine. Synthetic experiments were conducted in which the different end-members were synthesized in the presence of glycine as well as the amino acid alanine and …
-
BIO/ORGANIC COMPOUND DETECTION USING SODIUM SULFATE MINERALS: IMPLICATIONS IN THE SEARCH FOR LIFE ON MARS AND EUROPA
… Monument, Idaho was examined by laser desorption Fourier transform mass spectrometry (LD-FTMS), infrared spectroscopy and sulfur isotopic fractionation. These experiments show that bio/organic compounds are likely associated with the secondary Na-sulfate minerals, suggesting biological involvement …
-
BIO/ORGANIC COMPOUND DETECTION USING SODIUM SULFATE MINERALS: IMPLICATIONS IN THE SEARCH FOR LIFE ON MARS AND EUROPA
… Monument, Idaho was examined by laser desorption Fourier transform mass spectrometry (LD-FTMS), infrared spectroscopy and sulfur isotopic fractionation. These experiments show that bio/organic compounds are likely associated with the secondary Na-sulfate minerals, suggesting biological involvement …
-
Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry
… unit into the growing chain can be measured as a mass shift to the biosynthetic proteins by mass spectrometry. Specifically, Fourier-transform mass spectrometry (FTMS) (and an associated suite of custom MS tools) is a high-resolution analytical technique well suited to the study of NRPS and PKS …
-
Optimization of sample preparation in Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry of macromolecules
… ionization time-of-flight (MALDI-TOF) and Fourier transform mass spectrometry (MALDI-FTMS) analysis of low molecular weight polyvinyl acetate (PVAc) was developed and then applied to the characterization of commercially available chewing gum. The optimization of MALDI analysis of PVAc was …
-
Reengineering and Discovery of Nonribosomal Peptide Synthetases
… to the synthetases throughout biosynthesis. Mass spectrometry is an especially well suited tool for analyzing both the products of NRPS pathways and the machinery that produces them. A review of NRPS enzymology and contemporary mass spectrometric methods for their analysis is given in Chapter …