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Showing 1 to 7 of 7 for “"Formylglycine"”.
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Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
… katalysiert, wurde kürzlich identifiziert und formylglycine-generating enzyme (FGE) genannt. Genetische Defekte des FGE-Gens (sulfatase-modifying factor-1 gene, SUMF-1) führen zur Multiplen Sulfatasedefizienz (MSD), einer lysosomalen Speicherkrankheit, bei der die Aktivität aller Sulfatasen …
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Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
Ca-formylglycine ist der katalytische Überrest von sulfatases. FGly wird durch posttranslational Änderung eines Cysteine (Pro- und Eukaryotes) oder des Serins (prokaryotes) gelegen in konserviert erzeugt (C/S)xPxR Motiv. AtsB, ein vorausgesagtes radikales SAM Eisen-Schwefel Protein, ist ein …
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The asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB
… the first asymmetric syntheses of α-formylglycine dimethyl and diethyl acetals are described. This two-step approach employs a novel titanium enolate of a chiral glycinate, followed by addition of the requisite trialkyl orthoformate to provide a single diastereomer of the glycinate …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… the pharmacokinetics and therapeutic index. The formylglycine-generating enzyme (FGE) can be used as a tool for the site-specific oxidation of a cysteine into a Cα-formylglycine (FGly) within the recognition motif CxPxR. A mammalian cell surface display system was evaluated for the site-directed …
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Observing, Understanding, and Manipulating Biological Membranes
… targets a cysteine within the sequence to a formylglycine generating enzyme (FGE) that converts the cysteine to a formylglycine. Formylglycine bears an aldehyde on one of its residues. Aldehydes are found very rarely in the mammals and are also highly reactive with certain elements such as …
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Proteinkonjugationen durch Kupfer-abhängige Formylglycin-generierende Enzyme zur Generierung von Antikörper-Wirkstoff-Konjugaten
The formylglycine-generating enzyme (FGE) is utilized for the regioselective conjugation of proteins. In an oxygen-dependent reaction it catalyzes the formation of the non-canonical amino acid Cα-formylglycine (FGly) from the cysteine residue of a CxPxR-type core recognition se-quence. In addition …
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The roles of redox active cofactors in catalysis : structural studies of iron sulfur cluster and flavin dependent enzymes
… enzyme, anSMEcpe, which installs a required formylglycine posttranslational modification, refute this hypothesis. In these structures, substrate binding is distal from each enzymes' Aux clusters. However, the Aux cluster binding architecture shared between BtrN, anSMEcpe, and another AdoMet …