Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Formyl-peptide receptor"”.
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Targeting the formyl peptide receptor 1 for treatment of glioblastoma
Background and Aims Gliomas account for over half of all primary brain tumours and have a very poor prognosis, with a median survival of less than two years. There is an urgent and unmet clinical need to develop new therapies against glioma. Recent reports have indicated the overexpression of FPR1 …
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The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease
… be a viable therapeutic approach to tackling AD. Formyl peptide receptor 2 (Fpr2), which drives peripheral inflammatory resolution, is expressed in microglia. However, its functional role in neuroinflammation is unclear. This thesis provides evidence to support the peripheral findings of Fpr2 …
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Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury
… with bacterial-derived products, including formylated peptides, dominant in this process. In sterile tissue injury where no bacterial factors are present the mediators involved change but a hierarchy still exists. Mitochondrial formylated peptides are released following necrotic cell death …
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Host response in sepsis
… produce antibiotic substances (antimicrobial peptides, AMPs). Increased knowledge of the host response in sepsis will aid in refining and developing new treatment. We investigated the effect of the AMP, LL-37, on smooth muscle activity in isolated human omental vessels and found that it causes …
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Antioxidant studies of fullerene and metallofullerene derivatives and fluorescence studies of terbium-containing metallofullerene derivatives
… that consisted of a peptide that binds specifically to a formyl peptide receptor-1 (FPR-1), which expresses on activated macrophages, and a carboxyl-group-functionalized C60, which is the first discovered and most used fullerene is history. We showed that the …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… for being applied as radiotracers for imaging N-formyl peptide receptor 2 (FPR2), imidazoline-2 binding sites (I2BS) and angiotensin-converting enzyme 2 (ACE2) via PET. These molecular targets are important to understand the pathological processes in neuroinflammation and COVID-19. Over the …
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Annexin A1 im chronischen Nierenversagen
… Protein Annexin A1 und sein Rezeptor Formyl-Peptid Rezeptor 2 (FPR2) wurden in verschiedenen Organsystemen mit der Regulation von Fibroblastenaktivität in Verbindung gebracht, jedoch wurden ihre Expression und Funktion bei renalen fibrotischen Erkrankungen bisher nicht untersucht. Ziel …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
Infections of the lungs can cause tremendous tissue damage which often leads to pathogens spreading into the bloodstream. In the airways, Gram-negative bacteria produce biofilms through exopolysaccharide (EPS) that provides microbial protection; however, the impact of EPS on detection remains …