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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Formulation parameters"”.
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Optimization of granule size and tablet properties in a twin screw granulator: the influence of process and formulation parameters
… glycol (PEG) 4000, and the pharmaceutical formulation, α-D Lactose monohydrate + ibuprofen + PEG 4000 via a co-rotating granulator. Product characteristics (e.g., granule yield and strength, tablet crushing force, friability, and dissolution) are determined as being both formulation and …
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Evaluation of the Effect of Critical Process and Formulation Parameters on the Attributes of Nanoparticles Produced by Microfluidics. Design of Experiments Approach for Optimisation of Process and Formulation Parameters Affecting the Fabrication of Nanocrystals of Poorly Water-Soluble Drug Using Anti-solvent Precipitation in Microfluidic
… would be beneficial to patients. Process and formulation parameters were investigated to optimize the production and stability of nano particles of both drugs using Y shaped microfluidic reactors. IBU results show that the smaller the angle between the two inlets were the smaller the particle …
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Preparation of multifunctional nanoparticles using microfluidics
… conventional sterically stabilised liposomal formulations were prepared by microfluidic-assisted nanoprecipitation. The effect of processing and formulation parameters were studied, and the physicochemical properties of the prepared liposomes were determined. It was shown that the processing …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… with the use of polymers and surfactants (formulation parameters), understanding the impact of process parameters in the context of first-principle-based models, and production of truly nanosized drug particles (10-100 nm) with acceptable physical stability and minimal contamination with …
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Lactose Polymerization to Polylactose: Furthering Our Understanding for Commercialization
… was developed that allowed for the evaluation of formulation impact on the polymerization reaction and investigation of the use of permeate powder as the polylactose raw material. Water content and calcium phosphate concentration were the investigated formulation parameters. Elevated levels of …
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Correlation of Polymer Performance and Hansen Solubility Parameters
… intent of this research was to investigate formulation parameters and how they affect grout performance. It was learned that particle size and oil absorption (OA) value are important filler properties that affect performance as much as adequate packing density and optimal pigment volume …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… vivo performances. Therefore, in future studies, formulation parameters of Cur-Res SLNs should be further optimized to increase the drug loading.
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Modeling the Behavior of a Type-319 Aluminum Alloy During Quenching
… of this mechanical threshold follows a Voce Law formulation. Parameters of the model are derived from rapid, uniaxial tension tests conducted on samples cast in green sand. The model is used in a one-dimensional, semi-analytical solution to predict the deformation and residual stress of …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… empty NP size leads to preferred encapsulated NP formulation parameters, chitosan stabilizes the NP formulation bypassing the need for cytotoxic crosslinkers, and paraformaldehyde is able to kill virus prior to vaccine formulation while still preserving virus morphology sufficiently for immune …
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… using ternary phase behavior studies, and formulation parameters including silicone oil concentration, surfactant type, and surfactant concentration were optimized. The optimized formulations were characterized for particle size, span value, morphology, encapsulation efficiency, and in …
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
… both siRNA and mRNA delivery, but that several formulation parameters must be modified for optimal mRNA delivery. These include a lower molar percent of the ionizable lipid, having a higher total lipid to RNA weight ratio, and containing conical phospholipids instead of cylindrical …
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
… predictive thermodynamic modelling, ASD formulation design can be integrated into the extrusion process design to ensure the desired quality of the final dosage form. <br/><br/>This was the foundation for developing polymeric nanoparticles, the initial investigations focusing on one of …
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Development of Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants
… thermosensitivity of oMC. Aim 2 refined sIPN formulations produced when combining MC with oMC (MoMC) and mMC with oCMC (MoCMC) by varying the degree of oxidation, macromer concentration and ratio of oxidized to methacrylated polymer. The composite gels were characterized in terms of thermal …
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Evaluation of the critical parameters and polymeric coat performance in compressed multiparticulate systems
… analysis techniques. Different coating formulations were made of ethyl cellulose (EC) as a coating polymer and two different kinds of additives were incorporated into the polymeric coating solution. Triethyl Citrate (TEC) and Polyethylene glycol 400(PEG400) were used as plasticizers at …
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INVESTIGATION OF LIGAND SIZE ON TARGETED PLGA NANOPARTICLES FOR HER2 BREAST CANCER: TRASTUZUMAB AND ITS ScFv ANTI-HER2 ANTIBODY
… focuses on assessing the effect of various formulation parameters on targeting human epidermal growth factor receptor-2 (HER2) specifically in breast cancer. Poly (D, L-lactide-co-glycolide) (PLGA) polymer, which is approved by FDA, was used to form nanoparticles (NPs) encapsulating …
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Development and Optimisation of Nanoparticulate System for Brain Delivery of L-DOPA
… design (CCD) was applied for optimisation of the formulation parameters. The chemical and physical properties of PLGA NPs such as particles size, entrapment efficiency, zeta potential, porosity, surface charge and drug-polymer compatibility were measured. The cytotoxicity of PLGA NPs to the Caco-2 …
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In vitro Sustained Release Delivery System for Hydrogen Sulfide Analogs
… in this study a novel sustained release formulation of sodium hydrogen sulfide (NaHS) (a model H2S donor) was prepared, characterized, and its release profile was evaluated by quantifying the release of H2S. To quantitate H2S, mixed diamine reagent (0.06 ml) was added to 3 ml of standard …
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Development and Evaluation of a Niosome Carrier for Topical Use of Antioxidant
… for the determination of the compounds; preformulation studies were performed to study the physicochemical properties of the two compounds, such as partition coefficient, aqueous solubility and forced stability. C-loaded niosomes and EGCG-loaded niosomes were prepared using film hydration …