Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Forkhead transcription factor"”.
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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… which form a subgroup of the Transforming Growth Factor β (TGFβ) superfamily, regulate the expression several transcription factors implicated in gastrulation. Among these are the paired-like homeodomain transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, Gsc has been …
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Identification of new genes and pathways that act to delay C. elegans aging
… converges with the insulin-like pathway on a forkhead transcription factor DAF-16. We discovered that 14-3-3 proteins play a role in C. elegans lifespan determination. 14-3-3 proteins interact with the SIR-2.1 protein, and the 14-3-3 genes par-5 andftt-2 are required for the longevity mediated …
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The significance of DAF-16 and its role in the phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes
… these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… in silico within the upstream regulatory region. Forkhead transcription factor Foxo3 is the most responsive gene among transcription factors with altered expression during regenerative, cellular proliferation. p53 and p73 bind a Foxo3 p53RE and maintain active expression in quiescent liver. During …
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SMAD2/3 - FOXH1 regulation during cell cycle progression upon differentiation
… the molecular mechanisms orchestrating transcriptional networks during progression of the cell cycle upon differentiation remain to be fully uncovered. In this dissertation, I combined cell cycle synchronisation mediated by nocodazole with our well-established endoderm differentiation …
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Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
… to differentiation of Ch organs. fd3F encodes a forkhead transcription factor which has been identified as a potential downstream target of atonal in microarray experiments (Cachero et al., 2011). I have shown that fd3F is exclusively expressed in Ch neurons and their precursors in Drosophila …
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… controls the action of Akt homologues on the forkhead transcription factor DAF-16. The C. elegans Akt orthologue akt-1 also negatively regulates the DNA damage-dependent apoptosis of worm germ cells by indirectly interfering with activation of the key transcription factor CEP-1, the sole …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… the role of the thyroid hormone receptor (TR), transcriptional coactivators especially the peroxisome proliferator activated receptor gamma coactivator-1 (PGC-1α) and other transcription factors that act as accessory factors in T3 actions. </p> <p>Thyroid hormone receptors (TRα or TRβ) are part …
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Expression and function of basigin during early pregnancy and spermatogenesis
… results indicate that C/EBPβ may be one of the factors regulating the expression of BSG in mouse uterine epithelium. Decidualization of human endometrial stromal cells (HESCs) into decidual cells is carefully controlled, both spatially and temporally, by a balance of stimulatory and inhibitory …
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A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… require temporally and spatially regulated transcription factors (TFs), to induce the genes that are necessary to a specific cell type. In each cell a set of TFs interact with each other or activate their targets; as development progresses, transcription factors receive regulatory inputs …