Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Forkhead Transcription Factors"”.
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Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
Transcription factors regulate T cell fates at every stage of development and differentiation. Members of the FoxP family of Forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for regulatory T cell generation and function, and Foxp1 is necessary for the …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… and differentiation. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain essentially unknown. The work presented here describes the discovery of a role for the Foxo forkhead …
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The significance of DAF-16 and its role in the phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes
… these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
During my dissertation work I sought to better understand the conserved and human-specific functions of FoxP2. Intrigued by the enrichment of FOXP2 in the human subplate layer, I hypothesized that FOXP2 regulates evolutionarily distinct subplate gene expression patterns and tested this theory by …
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Cell Type-Specific Contributions of FOXP1 to Human Cortical Development
Pages vi-xv are misnumbered as pages v-xiv, pages 89-129 are misnumbered as pages 87-127, and pages 130-174 are misnumbered as pages 124-168.
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… in response to BCR stimulation. A variety of factors, including signal strength and duration, cytokine presence, and co-stimulation determine the ultimate B cell fate. In this thesis, the roles Foxo transcription factors play in maintaining B cell homeostasis will be explored. Foxo1, Foxo3, …
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… because of the implication that external factors, e.g. nutrition, are tightly coupled to the timing of differentiation. This proposal tests the hypothesis that FOXO, a crucial component of the InR pathway, mediates the regulation of developmental timing. The aims are the following: 1. …
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Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
Mutations of the forkhead domain transcription factors FOXP2 and FOXP1 are highly associated with neurodevelopmental disorders affecting speech and language. Across vertebrate species, their conserved expression patterns in the developing and adult brain predict important functions in neural …
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Transcriptional Regulation of Intestinal Stem Cell Lineage in Drosophila
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… TECs had reduced levels of the TEC master transcriptional regulator, Foxn1, as well as the expression of multiple chemokines. MiR-205 mimics introduced into miR-205 deficient fetal thymic organ cultures were able to restore the levels of Foxn1 and selected chemokines. This work demonstrates …
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Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function
… behavior. Mutations in the regulatory transcription factors expressed in SPNs can result in neurodevelopmental disorders (NDDs). Paralogous transcription factors Foxp1 and Foxp2, which are both expressed in the dopamine receptor 1 (D1) expressing SPNs, are known to have variants …
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DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION
… have allowed for identification of several transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary hormone deficiency …
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Control of M-G1 phase-specific expression in fission yeast
… its hallmark events, DNA synthesis and mitosis. Transcription is prominent among these processes, manifesting its importance for cell cycle controls by the large number of eukaryotic genes that are expressed at specific cell cycle times. Certain genes are cell cycle regulated in a number of …