Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Forensic toxicology"”.
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A comparison of derivatisation procedures for the detection of multiple analytes in systematic forensic toxicology
… and holds potential for future use in toxicology to replace diazomethane, a hazardous and toxic material. Method (c) gave derivatives with all test compounds except the secondary amine, methamphetamine, and the alcohol, morphine. The gas chromatographic behaviour of these derivatives …
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Applications of LC-MS/MS in forensic toxicology for the analysis of drugs and their metabolites
This thesis studied opioids and alcohol in forensic toxicology by LC-MS/MS, which avoids time-consuming procedures involving hydrolysis, extraction and derivatisation. Initially, a method was validated for quantification of opioids and unhydrolysed polar metabolites in autopsy specimens and was …
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Liquid Chromatography -- Tandem Mass Spectrometry Techniques for Drugs of Abuse as Applied to Bacterial and Forensic Toxicology
… and prevalence in analysis of both clinical and forensic specimens. Additionally, the human metabolites for these compounds had been previously identified and reference standards were commercially available.;A series of bacterial blanks were prepared in Reinforced Clostridial Medium and incubated …
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FORENSIC TOXICOLOGY IN UNCONVENTIONAL BIOLOGICAL MATRICES: THEEMERGING ARCHAEOTOXICOLOGICAL FIELD APPLIED TO BONE REMAINS ANDBRAIN TISSUE IN ANCIENT POPULATIONS
La tossicologia forense è una branca specializzata della tossicologia che svolge un ruolo cruciale nelle scienze forensi, rilevando e interpretando la presenza di sostanze esogene all'interno di matrici biologiche a fini medico-legali. La tossicologia forense include analisi sia qualitative che …
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Penetration of Carcinogen Across Porcine Esophagus and Applications of Disposable Pipette Extraction for Forensic Toxicology and Food Safety by Gas and Liquid Chromatography/Mass Spectrometry
<p>This dissertation focuses on the chemical analyses of N-nitrosonornicotine from (NNN) porcine esophageal tissue, benzodiazepines (BZDs) and steroids in urine, and toxins such as melamine and pesticides in various foods. The effects of menthol, ethanol and also acetaldehyde on the flux of NNN …
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Investigating the role of commonly misused drugs in suspected unnatural and/or unexplained deaths in Cape Town in 2022
… determining the cause of death. In 2022, the Forensic Toxicology Unit within the Western Cape Forensic Pathology Service piloted a targeted drugs analysis at Salt River Mortuary in Cape Town. This permitted an assessment of commonly misused drugs in suspected unnatural and/or unexplained …
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Development of a GC-MS method to determine toxic alcohols and their metabolites in postmortem blood
… as these are not routinely investigated in forensic toxicological analysis of biological samples. The purpose of this study was to modify and characterise a gas chromatography-mass spectroscopy (GC-MS) method for the quantitative determination of ETG, DEG, 1,4-BD, PGL, and the toxic …
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Bioaffinity-based Concept for Glyphosate Detection
… investigation capacities in the field of forensic toxicology. This study looks into the interaction between acetylcholinesterase (AChE) and glyphosate, specifically its potential suppression. The study optimizes parameters such as pH levels, enzyme concentrations, and substrate …
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
… 17 drugs of abuse in post-mortem hair samples in forensic toxicology cases. Using this method, it is possible to obtain maximum information from one hair sample which is extremely useful when the sample weight is limited. The ability of the LC-MS-MS method to extract and analyse a greater number …
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Paper spray mass spectrometry (PS-MS) for toxicological drug screens and biomonitoring of chemical warfare agent exposure
… contained herein presents strides toward forensic application of paper spray mass spectrometry, especially in disciplines related to forensic toxicology.
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Comparison of Supported Liquid Extraction and Solid Phase Extraction of Methamphetamine from Urine and Method Validation by Gas Chromatography-Mass Spectrometry
… extraction technique that is not widely used in forensic toxicology. SLE is also easier and less time consuming than traditional LLE (liquid-liquid extraction) and SPE (Solid phase extraction). This work will compare the extraction efficiencies between SLE and SPE for methamphetamine from urine …
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Expanding the Capabilities of Paper Spray Mass Spectrometry: High-Throughput Drug Screening and On-Paper Electrokinetic Stacking
… Chapter 2 demonstrates the potential of PS-MS in forensic toxicology through an automated high-throughput urine drug screening method. Chapter 3 investigates the negative impact of laser cutting paper spray substrates on sensitivity and provides practical remedies. The core of this work revolves …
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Stability of drugs and pesticides of forensic toxicological interest and their metabolites in biological samples
… storage has potentially serious implications in forensic toxicology and represents a challenge for the forensic toxicologist, especially in the interpretation of case results. The initial aim of the studies in this thesis was to evaluate the stability of some important drugs and compounds in …
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Death by electrocution: a retrospective analysis of three medico-legal mortuaries in the eThekwini district of KwaZulu Natal from 2006 to 2016.
… postmortem and histology reports, toxicology reports from Forensic Toxicology unit, contemporaneous notes, postmortem death registers, daily listings of postmortem case allocations and electronic postmortem databases. Data were collated and categorised on an Excel spreadsheet and …
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The prevalence of synthetic cannabinoids in forensic casework based on data from the Drug Enforcement Administration's National Forensic Laboratory Information System
… cases of overdose and even death. The National Forensic Laboratory Information System (NFLIS) collects drug report information involving narcotics, stimulants, depressants, hallucinogens, cannabis, and emerging drugs such as anabolic steroids, phenethylamines, and synthetic cannabinoids, to name …
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Hair analysis for drugs of abuse
… drugs of abuse is the first step in clinical and forensic toxicology. There are a large number of controlled substances and doping agents and novel compounds, which have yet to be characterised. A series of screening methods for drugs of abuse in hair were developed using LC-MS/MS and GC-MS/MS. …
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Forensic Analysis of Trace Evidence Fibers and Drugs of Abuse In Biological Matrices Using Chromatographic and Mass Spectrometric Methods
… The development of analytical techniques for forensic discrimination of fibers by micro-extractions of dyes followed by liquid chromatography (LC) or capillary electrophoresis (CE) with UV/visible diode array (DAD) or mass spectrometric (MS) detection is described. Separation and …