Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Foreign body response"”.
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… this approach holds greats potential, the immune response to biomaterials remains a major challenge to the field. Upon implantation of a material, the immune system will initiate the foreign body response, a cascade of inflammatory activity resulting in material fibrosis. For encapsulated cell …
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Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare
… These include weak adhesion with wet tissues, foreign body response, cumbersome application processes, and limited customizability. This dissertation presents a multiscale framework for addressing these obstacles, encompassing design strategies on the molecular, polymer network architecture, …
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Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
<p>Biomaterial implantation induces the foreign body response (FBR). Development of longer-term implants relies on the thorough understanding of the FBR. The progression of the FBR is regulated by a number of biomolecules including cytokines, chemokines, and matrix metalloproteinases (MMPs). The …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… are intricately involved in many biological responses. The foreign body response (FBR) is orchestrated by macrophages, wherein the phenotypes of these macrophages exist plastically along a spectrum from M1, proinflammatory macrophages to M2a, anti-inflammatory, pro-wound healing macrophages, …
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Multifunctional fiber-based neural interfaces
… probes and the neural tissues, which leads to foreign body response and functional device failure due to tissue scarring in the probe vicinity. To address the challenge, I developed fiber-based bioelectronic devices integrating diverse modalities within a single platform using thermal drawing …
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Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… life-threatening condition characterized by the body’s inability to produce sufficient insulin to properly regulate blood glucose levels. Despite advances in glucose monitoring/insulin delivery systems, the pancreatic islet is still functionally superior at regulating blood glucose levels. …
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Design and development of a fluid actuated neural probe for chronic sensing
… been hampered, owing to an inflammatory immune response in the vicinity of the implanted devices, concomitant with degradation of the electrode tissue interface. Current state-of-the-art electrode technologies often fail within a duration of a few weeks or months, limiting their lifespan. The …
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A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor
… is a chronic metabolic disorder whereby the body loses its ability to maintain normal glucose levels. Despite of development of implantable glucose sensors in long periods, none of the biosensors are capable of continuously monitoring glucose levels during long-term implantation reliably. …
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Nanotexturing for Biomedical Implants
It is known the foreign body response to implants, such as breast implants, includes a “walling off” of the implant, or a capsule formation. Previously, texturing has been shown to reduce this capsule formation, using methods such as polyurethane coatings [11-15]. A new proposed texturing method is …
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
The foreign body response is an inflammatory response to implanted materials and poses significant challenges for biomaterials-based medical applications, often leading to the degradation or fibrous encapsulation of an implanted device. The host response is largely dictated by the proteins that …
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In vitro screening of inflammatory cell responses to polypropylene-based surgical mesh used in the treatment of pelvic organ prolapse
… without pre-clinical or clinical testing. Foreign materials implanted in the body activate an immune response that can result in chronic inflammation often causing rejection of the material or pain. Explants from women with mesh complications have shown increased presence of inflammatory …
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Precision Medicine Approach to Improving Reconstructive Surgery Outcomes for Breast Cancer Survivors
… complication, though with different degrees of response, ranging from moderate scarring to major disfigurement and pain at the implant site. Presently, there is no way to predict the degree of contraction capsule formation that individual patients will suffer prospectively, nor is there clinical …
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Device design factors for enhancing the functionality of chronic intracortical microelectrodes
… is hampered by a series of inflammatory tissue responses. The consequence of the inflammatory response is the formation of a dense astroglial sheath around the vicinity of the electrode, impeding the electrical conduction between the electrode and neurons. Furthermore, due to the cascade of …
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Driving tissue morphogenetic cascades using tunable nanolayered surface coatings
… high fidelity and carry the risk of inducing a foreign body response. Orthogonally, therapies to alleviate diseases in the bone such as osteosarcoma and osteoporosis are of significant interest to improve clinical outcomes. However systemic delivery of these therapies leads to toxic side-effects …