Global ETD Search
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Showing 1 to 17 of 17 for “"Foreign Body Reaction"”.
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In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers
The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 …
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Modulating Neuroinflammation with Porous Templated Scaffolds
… performance remains unresolved. Via the foreign body reaction, macrophages and glial cells develop a “glial scar” around implants, increasing electrode impedance and leading to time-dependent declines in electrode performance. During the first two years of my PhD, I worked with Dr. Bill …
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Funktionelle und histologische Auswirkungen von Mesh-Implantaten im Tiermodell
… the recurrence rates markedly. Disadvantages are foreign-body-reaction, infections, adhesions, local wound complications like seromas and restriction of mobility by the rigid "shell". Three different types of mesh materials are compared in a rat experiment: a heavy-weight monofilament …
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3D BIO-PRINTED SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATION: AN INVIVO EVALUATION WITH FURTHER OPTIMIZATION
… marrow mesenchymal stem cells. No significant foreign body reaction was found. Scaffold extrusion and flattening was noticed in some subjects. Combining the scaffold with a Poly(ethylene) Glycol – Fibrinogen (PF) Hydrogel preliminarily improved bioactivity and catalysed cell differentiation. …
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In-vivo-Untersuchungen zur Gewebeverträglichkeit einer neuartigen, leichtgewichtig-großporigen Mesh-Generation zur Narbenhernienreparation
… results confirmed an inflammatory proliferative foreign-body reaction within different cell-turnovers in the recipient tissues. These reactions are mainly influenced by the used mesh modifications. As result, the different Monocryl®-constructions showed a remarkable decrease in inflammation and …
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Untersuchungen zur entzündlichen Fremdkörperreaktion an humanen Mesh-Explantaten unter Berücksichtigung von Risikofaktoren
… mesh implants leads to a chronic inflammatory reaction in the organism with formation of foreign-body granulation interfering with the process of mesh integration. The present paper examines the expression of inflammation parameters CD68, TGFß1, Cox2 as well as the cell proliferation and …
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A biohybrid bridge between brain and machine: Development and application of a neural implant using iPSC-derived neuronal membranes
… to achieve long-term stability *in vivo*. The foreign body reaction (FBR), an internal inflammatory mechanism triggered upon implantation of foreign objects, is responsible for fibrotic encapsulation of implanted neural probes, leading to a gradual decline in device functionality due to the …
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Molecular and Cellular Mechanisms of the Angiogenic Effect of Poly(methacrylic acid-co-methyl methacrylate) Beads
… factors. The resulting vessel-rich “alternative foreign body reaction” has exciting clinical implications as the polymer itself was found to exert a therapeutic effect in the absence of bioactive components or transplanted cells. Understanding the mechanism could lead to new applications for this …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
The foreign body reaction is a chronic inflammatory response to an implanted biomaterial that ultimately leads to fibrous encapsulation of the implant. It is widely accepted that the host response to implanted biomaterials is largely dependent on the species and conformations of proteins adsorbed …
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Molecular regulation of glioma cell migration: assessment and therapeutic implications
… of medical devices for the CNS, where a foreign body reaction is an undesirable event preventing long-term performances of devices intended for the treatment of chronic diseases. Promising results obtained over the last decades highlight EVs as candidates for therapeutic approaches in …
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Electronic implants with mechanically compliant coatings for interfacing with the nervous system
… This scar, which formed in a process called foreign body reaction (FBR), displaces nearby neurons, thus compromising electrical contact. Recent studies suggested that FBRs are triggered by the mechanical mismatch between the surface of the usually very stiff implant and the surrounding much …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… by the physiological host-implant response (foreign body reaction - FBR), which surrounds the implant with fibrotic connective tissue. Little is known about the cellular and molecular mechanisms of FBR in peripheral nerves and all the treatments to date have shown to be not specific and …
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
The foreign body response is an inflammatory response to implanted materials and poses significant challenges for biomaterials-based medical applications, often leading to the degradation or fibrous encapsulation of an implanted device. The host response is largely dictated by the proteins that …
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Comparison of conjunctival pedicle flap to corneal adhesion achieved by Tisseel® fibrin glue, ethyl cyanoacrylate adhesive, ReSure® hydrogel sealant, and conventional suturing with 8-0 VICRYL® suture
… increased corneal edema, increased scar tissue, foreign body reaction, suture abscess and dehiscence. In human ophthalmology, a number of sutureless techniques to affix ocular tissues are being explored. Specifically, these approaches include synthetic tissue adhesives, bioadhesives, and hydrogel …
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Untersuchungen zur extrazellulären Matrix unter Implantation differenter Netzmaterialien zum Bauchwandersatz
… pore vicrylmesh. The diameter of the resulting foreign body granulomas as a quantitative feature of the inflammatory reaction and the filament distance, on which a connective scar structure (scarred bridging of the pore) was analysed. Because in case of incisional hernia a disturbance of the …
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Knöcherne Integration und Biokompatibilität eines neuen resorbierbaren Polymers zur Schraubenaugmentation im osteoporotischen Knochen
… is no definitive answer as to what caused the foreign body reaction. Most likely several factors played a role, such as cytotoxicity of the degradation products, particles were broken off and the increased osmotic pressure within the implantation site. The inflammatory reaction and the degree …