Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"Forced Swim Test"”.
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
… in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing …
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Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
… depressive-like behavior. Saccharin preference testing 24h post hypoglycemia showed that mice receiving insulin (0.8 units/kg) had saccharin aversion (62% vs 90.5% of total fluid consumption). In addition, mice administered insulin had increased immobility in the forced swim test that took 48h …
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Environmental enrichment and serotonergic alterations on depressive-like states in rats
… significantly affecting serotonin. To test the efficacy of novel antidepressant drugs in the preclinical laboratory setting, researchers commonly implement the forced swim test (FST) for rats or mice. However, the effect of environmental enrichment on the expression of depressive-like …
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An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice
… two purposes of this study: the first being to test the modified Marmarou TBI model, and second to investigate anxiety- and depression-like symptoms in C57Bl6/J mice following a TBI. The modified Marmarou model used different weights (95g, 30g, & sham) to see how severity affected the …
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Modeling the Psychiatric Aspects of Polycystic Ovary Syndrome and Induced Stress
… in women that is characterized by excess testosterone and is associated with increased risk of infertility. Women with PCOS also show higher rates of depression and anxiety. Modeling PCOS in mice via administration of dihydrotestosterone (DHT) results in physiological alterations that are …
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EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS
… sensitive to CIE treatment. Here we sought to test the hypotheses that CIE would have less effect on negative affective behaviors in female rats and little or no increase in hippocampal excitability, with any increase in excitability being greater in the VHC than the dorsal hippocampus (DHC). …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… the progeny of vehicle-treated PS mothers’. The forced swim test (FST) was used to examine depressive-like behaviour in mice. Barley successfully increased mobility in mice exposed to the FST. Barley was antidepressant at low doses (0.8g/kg and upwards) if used subchronic; and at high …
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Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
… as high in females than in males. We set out to test the hypothesis that dim-light would interfere with the circadian rhythm of C57Bl/6 mice and induce both depressive-like and anxiety-like behaviours and that there would be sex-specific differences. Animals were either singly or group housed for …
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The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
… produced an antidepressant- like effect in the forced swim test, while intra-AcSh injection of MCH had opposite effects. Expression and biochemical studies demonstrated that MCH is modulating feeding behavior by interacting with the dopamine and glutamate pathways in the enkephalin and dynorphin …
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The crucial role of reelin in a preclinical model of depression
… behaviour, namely immobility in the forced swim test (FST). In the second experiment, the potential antidepressant effect of reelin (at either 3μg or 5μg either every 5 or 10 days) via lateral tail vein injections on depressive-like behaviour and reelin expression in the SGZ was …
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Serotonergic involvement in the behavioral depression produced by intermittent swim stress
… behavioral depression utilize continuous swimming or intermittent electric shock stress. Brown et al., developed a novel strategy that combined these stressors to produce the intermittent swim stress (ISS) protocol. The purpose of this thesis was to define the behavioral outcomes of ISS …
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Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
… performance of LVR and HVR rats in behavioral tests classically designed to measure non-wheel running locomotor activity behavior (i.e. open field test), sensitivity to drugs of abuse (i.e. cocaine-induced locomotor activity), anxiety-like behavior (i.e. elevated plus maze), depressive-like …
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Biobehavioral responses to immune skew and free fatty acids
… in the naïve state (Moon et al., 2011). To test our hypothesis that skewing the immune system can alter biobehaviors exhibited in mice, we utilized two distinct models. In Chapter 2, the project of endogenous immune skew, interleukin-4 (IL-4) knock-out (KO) mice were behaviorally phenotyped. …
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A study of the WKY as a rat model of depression
… effects of ketamine have not been previously tested in male WKY or MS SD rats and it was therefore decided to study the behavioural effects of ketamine in these rat models of depression. The aim of the first study was to characterize the WKY rat model of depression and to select the …
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Possibile ruolo del sistema endocannabinoide nel disturbo d’alimentazione incontrollata (binge eating disorder): studi comportamentali, farmacologici e biochimici
… over prolonged periods of time. As revealed by forced swim test, animals with binge eating behavior did not show a depressive like behavior compared to control animals. However, using the elevated plus maze, an anxiety like behavior was highlighted in those animals before access to margarine …
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Immediate and enduring effects of corticosterone administration during adolescence and adulthood on anxiety and depressive behavior in male rats
… daily for 16 days. Ha l f of the rats were then tested on the elevated plus maze (EPM) one day after their last injection, and the following day were tested on the forced swim test (FST). After the FST, which is a stressor, blood samples were collected at three time points, and the plasma …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… cage and reduced depressive-like behavior in the forced swim test. Conversely, long-term EE reduced locomotion in the open-field test. Additionally, short-term EE showed anxiolytic effects in the elevated zero maze, while these effects were lost after long-term EE. EE, irrespective of duration, …
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Gut microbes and brain function
… understanding the potential of targeting the intestinal microbiota to prevent and treat such disorders. Preclinical data strongly support the view that microbe manipulation using probiotics and prebiotics to enhance the host-microbe symbiotic relationship has great potential in the future …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… PPARα agonists as clofibrate by motor activity test to evaluate possible motor impairments, the forced swim test (FST) for the antidepressant activity, the elevated plus maze (EPM) and the social interaction test (SI) for anxiolytic like effects. The standard antidepressant drugs used in FST …
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Neurodevelopmental and Behavioral Consequences of Serotonin System Disruption via Early Life Exposure to SSRI Antidepressants
… displayed increased passive coping in the Forced Swim Test but showed no differences in anxiety-like behavior. In addition to emotional behaviors, dams with a history of early-life SSRI exposure exhibited decreased maternal care, including diminished arched-back nursing, reduced licking and …
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