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Showing 1 to 2 of 2 for “"Fom3"”.
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Studies of unusual catalysis : a tale of four enzymes from diverse biosynthesis pathways
… from thiosulfate to SCPs. The last two enzymes, Fom3 and OxsB, belong to the cobalamin-dependent radical SAM class of enzymes. While these enzymes are believed to operate with unprecedented chemistry, they remain poorly understood and understudied. Fom3 is proposed to methylate an unactivated …
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Investigations of metalloenzymes involved in bacterial natural product biosynthesis
… and purify the fosfomycin biosynthetic enzyme Fom3 from Streptomyces wedmorensis, a methyltransferase in the radical S-adenosylmethionine (SAM) superfamily, with its required iron-sulfur cluster and cobalamin (B12) cofactors. The methyl transfer reaction catalyzed by Fom3 was then investigated …