Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Follistatin"”.
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Role of the Activin/Follistatin system during angiogenesis and tumor progression
… differentiation and apoptosis in many tissues. Follistatin (FS) is a functional antagonist of AC. The FS/AC system regulates endothelial cell (EC) proliferation. AC inhibits EC proliferation in an autocrine (constitutively expressed by ECs) and paracrine manner, contributing to maintenance of …
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An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis
… at least partially through increasing follistatin gene expression and decreasing BMP signaling. Using cultured explants of the heart region, we demonstrated that addition of BMP4 and activin rescued the inhibitory effects of follistatin and RA on cardiomyocyte differentiation. These …
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THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS
… clinical evidence that the upregulation of follistatin results in better muscle growth and strengthening. Moreover, the use of adeno-associated viruses ensures the efficient, specific delivery of the transgenes to the muscle that requires it. Furthermore, the alternatively spliced variant of …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… factor that is reportedly inhibited by HDACs-follistatin. Anti-miR-1 LNA dampens follistatin mRNA level, which is rescued by HDAC inhibitor trichostatin A (TSA). Concurrently, anti-miR-1 LNA also inhibits myotube fusion, which could be rescued by either introducing recombinant follistatin, or …
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Pattern formation and essential responses for regeneration in planarians
… requirement of planarian regeneration. follistatin, which encodes an extracellular Activin inhibitor, is required for the missing tissue response after head amputation, and for subsequent regeneration. We found that follistatin is required for the missing tissue response regardless of …
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Molecular mechanisms of regeneration initiation and dorsal-ventral patterning in planarians
… A homolog of the TGF-[beta] inhibitor follistatin was identified in this manner and found to be required for regeneration. Furthermore,follistatin was required for mounting a number of regeneration-specific responses to injury. A suppression screen of candidate planarian TGF-[beta] …
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Molecular insights into signalling mechanisms within TGF-β superfamily
… of the absence of the solution structure of follistatin (an extracellular inhibitor of several TGF-β superfamily signalling molecules) it is unclear how its C-terminal tail affects its function. In this work I employed a combination of small-angle X-ray scattering (SAXS) and biophysical …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… (RT-PCR) was performed to measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the periods of …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
… ES-Zellen erhöht war, darunter Axin2 und Follistatin. <br>Im weiteren Verlauf der Arbeit konnte gezeigt werden, dass Axin2 und Follistatin direkte Zielgene des Wnt/beta-Catenin-Signalwegs sind. Durch die in vitro Charakterisierung von 5’-regulatorischen Sequenzen in …
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Characterisation of cytokine secretion in malignant gliomas
… sera and CSF of the different groups. These were follistatin, fibroblast growth factor (FGF), granulocyte – colony stimulating factor (G-CSF), soluble human epidermal growth factor receptor 2 neural (sHER2neu), soluble interleukin-6 receptor alpha (sIL-6R alpha), platelet-derived growth factor - …
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Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence.
… gradient from the site of the oocytes. Morever, follistatin and a BMP6 neutralizing antibody, which antagonized the anti-apoptotic effects of BMP15 and BMP6, respectively, whether alone or combined, blocked ~50% of the antiapoptotic actions of oocytes. These results demonstrated that OSFs, …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
… immunosorbent assay (ELISA) of S100A8/A9, follistatin-like protein 1 and interleukin-18 (IL-18). Of the AOSD patients, follow-up samples were collected from 16 patients after resolution of disease activity. Furthermore, S100A8/A9 expression levels in biopsy specimens obtained from 26 AOSD …
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Malignant Glioma: Chemosensitivity testing and Biomarkers
… of VEGF and PDGF-BB, this is the first report of Follistatin, IL-6, IL-8 and IL-10 as biomarkers for malignant gliomas. Overall age and gender of patients did not affect the biomarker results. Brain tumours represent 2% of all cancers in the UK. Early detection and treatment of glioblastoma is …
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Sexual differentiation of somatic and germ cell lineages of the mouse gonad
… In XX gonads I found that one ovarian gene, follistatin, is also expressed in a center-to-pole pattern, whereas a second ovarian gene, Adamtsl9, is expressed in an anterior-to-posterior wave. In addition, these ovarian genes are upregulated at the poles of XY gonads, suggesting that ovarian …
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Regulation of skeletal myogenesis by the mTOR signaling network
… suppression of HDAC4 results in production of follistatin and subsequent myocyte fusion. Collective evidence strongly suggests that follistatin is the longsought mTOR-regulated fusion factor. In summary, these findings unravel yet another link between mTOR and microRNA biogenesis, and identify …
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The structure of human pro-myostatin and molecular basis of latency
… which is resistant to the natural inhibitor follistatin and exhibits significantly weaker bioactivity than the mature growth factor. A number of distinct structural features combine to stabilise the interaction between pro and mature domains and in doing so confer latency to the pro-complex. …