Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Follicular helper T-cell"”.
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
Background and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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Immune responses to AAV gene therapy in the ocular compartment
… be used to deliver therapeutic genes to diseased cells in the eye. Whilst some consider the eye to be an immuneprivileged organ, recent reports have begun to suggest that injection of AAV may elicit local and systemic immune activation. The objective of this thesis was to further our understanding …
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Engineering kinetics of immunotherapies and vaccines
… show how these kinetics can significantly impact cellular and humoral immune responses, and carried out detailed investigations into the underlying mechanisms that govern these temporal effects. Firstly, imidazoquinolines (IMDs), small molecule agonists of Toll like receptor (TLR)-7 and/or TLR-8, …