Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1149 for “"Folding"”.
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Map folding
… are given for special cases of 2 x n map folding. This thesis goes on to extend this algorithm to optimization variants of the problem. In particular, by certain metrics it finds the simplest flat folded state achievable by a given 2 x n map in polynomial time. This thesis also provides …
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Folding Wall
Assisted living means to undergo drastic changes in life. Most significant is the change from a familiar domestic environment to a care based situation that includes incremental levels of medical support, often in spaces that are modeled after hospitals. The core of this thesis is grounded in the …
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Folding City Flats
<p>This collection of poems draws largely upon language to construct unlikely images and scenes that evoke a sense of displacement. Although the poems may deviate stylistically, they maintain a lyric sensibility that takes its grounding from a Modern sensibility while also heavily influenced by …
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Folding: A House
Folding: A House is a study of the continuity of floor, wall and ceiling within the context of a house. With this method of continuity through folding, a strong directionality occurs within the spaces. The relationship among the different folds and between the folds and their enclosures is a …
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Cotranslational Folding of CFTR
… throughout the CFTR protein result in misfolding are unclear. The correction of these processes and ultimately the treatment of CF require elucidation of these mechanisms. In this report, CF-causing mutations in the first transmembrane (TM) spanning domain (TMD1) that result in CFTR …
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Optical SNS folding circuit design
… this thesis the optical processor for an 8-bit folding ADC is designed. LabVIEW simulation of the interferometers is used to simultaneously allow for the testing of the digital circuit boards and the development of the optical front end of the ADC. Each component considered for the 8-bit optical …
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Folding patterns in protein sequences
… dataset of globular proteins, here we explore folding signals affecting sequence conservation and, in particular, motifs. Initially, we aimed at determining whether folding signals are encoded in sequence motifs. It was found that those regions best conserved in evolutionary time (i.e., …
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Cellular influence on protein folding
Advances in the study of protein folding and structure have greatly expanded our understanding and ability to predict and modify protein structure and, increasingly, even function. Attention has now turned to developing a better understanding of how protein structure, function, and folding interact …
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Glassy models of protein folding
… physics of disordered materials to study protein folding. The first chapter consists of a general introduction to proteins and protein folding. In Chapter Two we develop a simple protein folding model and use a random energy approximation to calculate its equilibrium properties. The model has …
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Energy Landscapes for Protein Folding
… folded structure). A microscopic description of folding is an important prerequisite for elucidating the underlying basis of protein misfolding and rational drug design. However, protein folding occurs on heterogeneous length and time scales, presenting a grand challenge to both experiments and …
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Beak design in folding-shearing
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Direct observation of fast protein folding: Distinct nanosecond and microsecond events in the folding of apomyoglobin
The rapid refolding dynamics of horse apomyoglobin are followed by a new temperature-jump fluorescence technique on a nanosecond to 0.5 millisecond time scale in vitro. Collapse to a compact state is complete in under 20 microseconds under strongly-nativizing conditions. The intrinsic tryptophan …
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RNA folding via algebraic dynamic programming
… open problems. Ab initio RNA secondary structure folding of a single sequence was chosen as a perfect fit to the requirements. First, because of the compactness of the field, showing a clear path from the first description of the Nearest Neighbor model by Tinoco and others in a Nature paper from …
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Protein mis-folding and human disease
… and V30M transthyretin (TTR) protein. TTR misfolding has been<br/>implicated in number of human diseases such as senile systemic amyloidosis,<br/>familial amyloid polyneuropathy and familial amyloid cardiopathy. TTR protein is a<br/>thyroxine binding protein (14kDa) existing as a tetramer in …
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Folding and aggregation of amyloid peptides
… and Aβ(10-35)-NH2 in aqueous solution. The folding and aggregation of Aβ(25-35) were studied at neutral pH and 293 K. Aβ(25-35) monomers mainly adopt β-hairpin conformations characterized by a β-turn formed by residues G29 and A30, and a β-sheet between residues N27–K28 and I31–I32 in …
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Investigation Into Protein Folding and Misfolding
… of the genetic code is known as the 'protein folding problem,' which is the primary focus of this work. This problem is focused on understanding the fundamental features that dictate how the primary structure of amino acids transition along a thermodynamic and kinetic pathway into a …
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Chain dynamical theories of protein folding
Completely microscopic theories of protein folding must take into account chain dynamics. The energy landscape description of protein folding accommodates two rather distinct behaviors of the polypeptide chain: the glassy dynamics expected for heteropolymers with random interactions and the …
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Procollagen Folding in Health and Disease
… appreciated mechanisms involved in procollagen folding in health and disease. In Chapter 2, we explore the molecular basis of procollagen assembly, and uncover a new role for the triple helical domain sequence in guiding trimer assembly. In Chapters 3 and 4, we develop, characterize, and deploy …
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Understanding collagen-l folding and misfolding
… of C-propeptide function both in collagen-I folding and also in diverse biological processes. In order to address these questions, we created and validated constructs that allow the independent expression of the C-propeptide domains.
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