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Showing 1 to 13 of 13 for “"Foldamers"”.
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Synthesis, Characterization and Device Studies of Conjugated Foldamers
… stability has remained a major issue. Conjugated foldamers can be considered as a viable option to achieve the desired stability. Conjugated foldamers are generally driven by secondary interactions such as π-π stacking, H-bonding, and solvophobic interactions. We have designed foldamers based on …
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Supersonic jet spectroscopy of synthetic foldamers, multichromophores, and their water containing clusters
… effort to bridge the complexity gap: synthetic foldamers, multichromophores, and water containing complexes. ^ For the synthetic foldamers, a set of 21 conformations that represent the full range of H-bonded structures were chosen to characterize the conformational dependence of the vibrational …
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Single-conformation spectroscopy of hydrogen bonding networks: Solvation, synthetic foldamers, and neurodegenerative diseases
<p>The hydrogen bond is one of the most important interactions in natural processes ranging from protein folding to chemical reactions. Two complementary methodologies are applied to understanding this important interaction: top-down and bottom-up. Top-down methods use large molecules, such as …
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Reactive Sieving With M-Phenylene Ethynylene Foldamers: Effects of Structural Modification on Reactivity
… nature of the host-guest interaction between mPE foldamers and the methylsulfonate esters used to study reactive sieving, a set of parameters for both the mPE foldamer and the methylsulfonate guests were developed for CHARMM-based molecular dynamics simulations. A total of 14 simulations were …
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SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
Carbohydrates are complex molecules currently under deep investigation for the multiple roles they have in Nature: from source of energy, bricks of cell surface to several biological processes1. In the past years carbohydrates have been used in many applications: in the pharmaceutical field they …
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Helical Pitch, Hydrophobic Binding, Chiral Templation, and Supramolecular Chelation of M-Phenylene Ethynylene Foldamers
… ethynylene (m PE) folding oligomers or foldamers were designed, synthesized, and studied. These chain molecules have been shown to adopt a helical conformation under appropriate conditions in solution. A series of double TEMPO spin labeled oligomers were studied by electron spin …
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Synthesis and Physical Properties of Helical Nanosized Quinoline-based Foldamers: Structure, dynamics and photoinduced electron transport
… electron transport) of nanosized quinoline-based foldamers have been explored. With double segment strategy, a variety of helical nanosized foldamers (up to 96 quinoline units) were successfully prepared based on 8-aminoquinoline-2-carboxylic acid monomer. The dynamic properties in gas phase and …
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Phenylene Ethynylene Foldamers: Cooperative Conformational Transition, Twist Sense Bias, Molecular Recognition Properties, and Solid -State Organization
Several series of sequence-specific meta connected phenylene ethynylene oligomers were designed, synthesized, and studied. The oligomers were determined to adopt highly ordered conformations both in solution and the solid-state. The conformational transition from a random coil to helical …
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Ultraviolet and Infrared Spectroscopy of Synthetic Foldamers, Aib Homopeptides, and Solvated 1,2-Diphenylethane in the Gas Phase
… <p>Model β/γ-peptides known as synthetic foldamers and aminoisobutyric acid (Aib) homopeptides incorporate structural constraints that are designed/known to impose particular structural motifs. Here the ability of a β/γ-dipeptide to replicate the backbone length of an α-tripeptide and …
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Hexagonally-Packed Helical Oligo(m-Phenylene Ethynylene) Nanotubules via Structural Modification and Guest Templation
… sequence-specific oligo(m-phenylene ethynylene) foldamers were designed, synthesized and studied. The foldamers were examined with the intention of translating previously reported solution-phase concepts into the solid-state realm. Specifically, the employment of the highly ordered helical …
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De Novo Design of secondary structures: Synthesis and conformational studies
… discrete and predictable folding propensities (“foldamers”) will provide a basis for design of molecular machines with unique capabilities. The foldamer approach complements current efforts to design unnatural properties into polypeptides and polynucleotides. The aim of this thesis is the …
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Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
… macrocycles, conjugated polymers and conjugated foldamers. Novel PAH-based conjugated macrocycles have been developed for electronic applications. Specifically, two imine-based shape-persistent macrocycles containing triphenylene building blocks have been synthesized. Their stable conformations …
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DNA Constraints for Rational Control of Macromolecular Conformation
… such as proteins and non-biological foldamers.