Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Foldamer"”.
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Hexagonally-Packed Helical Oligo(m-Phenylene Ethynylene) Nanotubules via Structural Modification and Guest Templation
… sequence-specific oligo(m-phenylene ethynylene) foldamers were designed, synthesized and studied. The foldamers were examined with the intention of translating previously reported solution-phase concepts into the solid-state realm. Specifically, the employment of the highly ordered helical …
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Synthesis and Physical Properties of Helical Nanosized Quinoline-based Foldamers: Structure, dynamics and photoinduced electron transport
… electron transport) of nanosized quinoline-based foldamers have been explored. With double segment strategy, a variety of helical nanosized foldamers (up to 96 quinoline units) were successfully prepared based on 8-aminoquinoline-2-carboxylic acid monomer. The dynamic properties in gas phase and …
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Reactive Sieving With M-Phenylene Ethynylene Foldamers: Effects of Structural Modification on Reactivity
… nature of the host-guest interaction between mPE foldamers and the methylsulfonate esters used to study reactive sieving, a set of parameters for both the mPE foldamer and the methylsulfonate guests were developed for CHARMM-based molecular dynamics simulations. A total of 14 simulations were …
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Synthesis, Characterization and Device Studies of Conjugated Foldamers
… stability has remained a major issue. Conjugated foldamers can be considered as a viable option to achieve the desired stability. Conjugated foldamers are generally driven by secondary interactions such as π-π stacking, H-bonding, and solvophobic interactions. We have designed foldamers based on …
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An approach to catalytic asymmetric electrocyclization
Chapter 1 outlines the development of a catalytic electrocyclic process and its exploitation in asymmetric synthesis. Since Woodward and Hoffmann delineated a rationale for the mechanism and stereochemistry of these reactions they have become powerful synthetic tools. The aim of this project was to …
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De Novo Design of secondary structures: Synthesis and conformational studies
… discrete and predictable folding propensities (“foldamers”) will provide a basis for design of molecular machines with unique capabilities. The foldamer approach complements current efforts to design unnatural properties into polypeptides and polynucleotides. The aim of this thesis is the …
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SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
Carbohydrates are complex molecules currently under deep investigation for the multiple roles they have in Nature: from source of energy, bricks of cell surface to several biological processes1. In the past years carbohydrates have been used in many applications: in the pharmaceutical field they …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
Tauopathies refer to neurodegenerative disorders characterized by the presence of abnormal aggregates of Tau protein, leading to the formation of neurofibrillary tangles (NFTs) within neuronal cells. Tau, a protein associated with microtubules (MTs), plays a crucial role in regulating the dynamics …