Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 231 for “"Fold-in"”.
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Structure and molecular recognition in riboswitches
Riboswitches are cis-acting gene regulatory RNAs, which function without involvement of proteins. They have been implicated as drug targets and are attractive systems for the study of RNA-ligand binding and RNA folding. The purine riboswitch was used as a model system for RNA-ligand docking. …
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Investigation of the effects of Elicitation and Quorum sensing on Monascus purpureus C322
Monascus purpureus, traditionally used in Chinese red yeast rice, is known for its production of lovastatin—a compound effective in reducing cholesterol—and various pigments (red, yellow, and orange). This study aims to enhance the production of these metabolites using biotic elicitors, such as …
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Understanding, Optimization, and Application of Phosphite Dehydrogenase: Advancing NAD(P)H Regeneration
NAD(P)H regeneration is an industrially important process that supports biocatalytic reactions that utilize these cofactors. PTDH shows promise for NAD(P)H regeneration and was therefore optimized for industrial application. The cofactor specificity of PTDH was relaxed by rational design using the …
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Actinorhizal Plant Nodulation and Nitrogen Fixation in Natural and Experimental Systems
In a separate study, water-retentive polymer carriers of Frankia inoculum were applied as a root dip to Alnus glutinosa and Casuarina equisetifoloia seedlings. This treatment increased nodulation 5- to 10-fold in greenhouse experiments and also of A. glutinosa in a field experiment.
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Novel non-viral delivery systems for cancer gene therapy
… cancer therapy. However, due to lack of targeting efficacy, their therapeutic applications are still limited. In this present study, our aim was to investigate the efficacy of four formulations of modified generation- 3- diaminobutyric polypropyleneimine (DAB), by determining their …
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Structural determinants of mutability across cancer genomes
… characterised and actuated by somatic mutations. In cancer the distribution of mutations across the genome is inhomogeneous, with genomic and epigenomic features influencing mutational patterns. Previous studies have indicated that chromatin organization and replication time domains are correlated …
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Increase in heat resistance of <u>Listeria monocytogenes</u> Scott A by sublethal heat shock
… Listeria monocytogenes Scott A were heat shocked in Trypticase Soy + 0.6% Yeast Extract broth at 40, 44, and 45°C for 3, 10 and 20 min at each temperature, followed by heating at 55â C for 50 minutes in order to determine an optimum heat shock response. Most heat shock temperatures significantly …
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Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma
The incidence of Oesophageal Adenocarcinoma (OAC) has risen six-fold in the western world in the last forty years but response rates to chemotherapy are low and survival is poor. Increased molecular understanding of this heterogeneous disease is needed to overcome resistance to chemotherapy and …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… therapies. MicroRNAs (miRNAs) are dysregulated in a variety of disease states, suggesting that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA changes in ALS model SOD1G93A rodents identified 12 miRNAs as significantly changed. …
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the disease has increased by two to three-fold in industrialized countries, with higher incidences in …
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Mathematical methods for protein structural motif recognition
In this thesis, two algorithms for protein structural motif recognition are presented. A program is described which successfully recognizes the occurrence of the right-handed parallel 8-helix fold from protein sequence data alone. When run on sequences of unknown structure the program identifies …
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Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma
<p>Cutaneous squamous cell carcinoma (cuSCC) is the second most common skin cancer, for which long term UV exposure and chronic wounding are the dominant risk factors. Despite these clinically established connections, little is understood about the early molecular response of human skin to UV …
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Salivary Reduction of Dietary Nitrate
Nitric oxide (NO) is an important cellular signaling molecule known mostly for its vasodilatative effects. Nitrate (NO3-) acts as an important NO source through reductive physiological pathways. Basal plasma NO3- levels are a sum of the oxidation of endogenous NO and ingested dietary NO3-. …
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Zipped assembly
… functions on the premise that fundamental building blocks assemble into chains, are zipped into strands and folded into structures. This thesis is a macroscale implementation that aims to do the same, assemble, zip and fold, in an inorganic system. This system, Zipped, utilizes distributed …
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The P22 Xis Protein: Regulation of Bacteriophage P22 Site -Specific Recombination
… were isolated and assayed for excision system in vivo, to quantify their excision activity relative to wild-type Xis. Mutants S18F, R19A, G29S, G29D, A33P, R35C, D37G, S43F, S43P, P44L, L46F, A51T, and A51V were found to be defective in stimulating excision. Additionally, truncation mutants …
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Developing Novel Non-Natural Amino Acids as Spectroscopic Reporters of Structure for Peptide Systems
Properly folded proteins are essential to living organisms. Mis-folded proteins can lead to some serious diseases such as Alzheimer's disease, Lou Gehrig's disease (ALS), and muscular dystrophy which affect many people. The key to potentially preventing such diseases lies in understanding how and …
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Kinematics of detachment folding, Appalachian Valley and Ridge, West Virginia
This study assesses the geometry and kinematics of a fold at the east edge of the Nittany Anticlinorium, Appalachian Valley and Ridge Province, West Virginia. Regional deformation consists of minor to major folds within two vertically stacked thrust sheets. Geometric analysis of a first-order fold …
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Perceptions of importance of diagnostic competencies among educational diagnosticians.
This research was two-fold in its purpose: the first purpose being to assess the perceived relevance of the current state competency standards adopted in Texas by the State Board for Educator Certification (SBEC) as they apply to the work of the educational diagnostician and the second being to …
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Bereavement in children : a school based intervention programme
The consequences of childhood bereavement are two-fold, in the pain he/ she suffers at the time of the death, and in future psychiatric disorders which can follow unresolved mourning. The bereaved child needs a familiar and responsible adult outside the family to help him/her cope with his/her …
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Survival of ice nucleation-active and genetically engineered inactive strains of Pseudomonas syringae
The survival of ice nucleation-active (INA) and genetically engineered non-INA strains of Pseudomonas syringae was compared under starvation and freezing conditions. In starvation experiments, both strains displayed similar survival curves and recovery from starvation was nearly identical for the …
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