Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Folate receptor"”.
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Immunotherapy of Folate Receptor Expressing Cancers
The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction. With the introduction of multiple folate-targeted drugs into the clinic, the question has arisen regarding how frequently a patient can be dosed with …
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The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates"
… <p>Approximately 90 percent of EOC are folate receptor alpha (FRα) positive with the extent of receptor over-expression corresponding with stage and grade of disease. FRα based therapies are a subject of increasing interest warranted by a growing number malignancies, from various tissue …
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Folate Receptor-Targeted Transplacental Delivery of Digoxin for the Treatment of Fetal Arrhythmia
… the transplacental transfer of digoxin due to folate receptor-mediated endocytosis. Folate receptors are highly expressed in the placental trophoblast throughout pregnancy due to the importance of folic acid in fetal and placental development. We believe that this novel treatment strategy may …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… depend on immune effector cells that express Fc receptors (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma receptor IIIa (FcgammaRIIIa) and various …
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FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER
… therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this …
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
… acid that specifically targets the high affinity folate receptor (hFR) overexpressed on more than 80% of ovarian tumors. We tested the hypothesis that folate-dendrimers can specifically image tumors expressing the hFR with MRI. Conjugating folate to dendrimers results in specific binding of these …
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Targeting brain inflammation with bioconjugated nanoparticles
… when compared to the control. Additionally, folate receptor-α (FR-α) was also overexpressed, confirming that our model will function appropriately for specific targeting experiments. Cellulose nanocrystals are rod-like particles, approximately 5 nm wide and 100-150 nm long. The surface area …
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Synthesis and Characterization of Thermally Responsive Nanocapsules Surface Decorated With Folic Acid For Targeted Drug Delivery and Cancer Destruction
… them with folic acid (FA, to target folate receptor overexpression in cancer cells) and/or polyethylene glycol (PEG, for stealth to minimize opsonization in serum). The surface-modified nanocapsules are thermally responsive in size, which enables encapsulation of Doxorubicin (Dox) at …
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Production and Surface Modification of Protein Microspheres
… and Lee has shown the successful targeting of folate labeled polyethylene glycol (PEGylated) liposomes to tumors that express folate receptors. Adaptation of this technology allowed approximately 6000 folate-PEG polymers per microsphere to be covalently linked to the surface of the albumin …
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Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
… tissues. Based on this, we explored the use of a folate ligand to selectively deliver siRNAs to cancer cells via the folate receptor. This receptor is highly overexpressed in numerous cancers and has become an important molecular marker in cancer research. Here, we show that centrally modified …
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Interaction Forces And Reaction Kinetics Of Ligand-Cell Receptor Systems Using Atomic Force Microscopy
… and can yield important parameters about ligand-receptor interactions on live cells. However, the standard theory for analyzing rupture force data does not fit the experimental rupture force histograms. Most of the experimental measurements of rupture force data generate a probability …
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Release, Stability and Functionality of Nanodelivered Hydrophobic (Lutein and Beta-Carotene) and Hydrophilic (Folic Acid) Antioxidants Using Zein Nanoparticles
… uptake, particularly by the over-expressing folate-receptor cells indicated that zein nanoparticles can be developed into versatile targeted delivery systems. These findings strongly support the ability of zein nanoparticles to act as effective antioxidant nanodelivery systems for innovative …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… virus in VBNPs and specifically targeted them to folate-receptor bearing tumor cells by surface conjugation to folate. The VBNPs killed tumor cells by apoptosis and induced proinflammatory and chemotactic cytokines. The VBNPs, although not curative, were able to limit the progression of …
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Integrating High-throughput Technologies for the Identification and Validation of Novel Ovarian Cancer Biomarkers
… Serum validation revealed two markers - folate receptor 1 and kallikrein 6 - to have comparable diagnostic ability to the clinically-approved markers, albeit with similar limitations in their ability to detect patients of the non-serous histotypes as well. Fortunately, the validation of …
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Selective delivery of arsenic trioxide to HPV positive cervical cancer cells with targeted liposomes
… for selectively targeting HPV positive cells. Folate receptor (FR) was found as the most abundantly expressed receptor on HeLa cells, therefore, folic acid (FA) was chosen as the targeting ligand. FA-liposomal-ATO were synthesised by linking liposomal-ATO to FA using 5000kDa PEG spacer, which …
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The Potential of Cellulose Nanocrystals in the Detection and Treatment of Cancer
… electroporation (IRE)-induced cell death in folate receptor (FR)-positive cancers. To accomplish this task we have prepared stable and reproducible CNCs from wood pulp via sulfuric acid hydrolysis. Furthermore, we have functionalized the surface of these nanoparticles and conjugated them with …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… Chapter 3 covers the discovery of increased folate receptor gamma (FOLR3) specifically in the liver of NASH patients. Initially, FOLR3 was predicted to impact one-carbon metabolism through folate metabolism, but molecular characterization found FOLR3 drives liver fibrogenesis independent of …
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Development of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics
… commonly overexpress specific antigens (e.g., folate receptor alpha [FRa] in ovarian cancer), cell receptor expression is an emerging biomarker that can be leveraged to localize malignant cells and guide patient-specific treatment strategies. Molecular imaging strategies are being explored to …
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Progressing the Synthesis, Coordination Chemistry and Biological Evaluation of Phenanthrolines
… complexes with the view to selectively target folate receptor expressing cancer cells and activated macrophages. A selection of complexes were screened, in vitro, for growth inhibition activity against a range of fungal and bacterial pathogens and were found to have broad spectrum activity. The …
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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
… by attachment of cell-specific ligands such as folate and biotin. Folate carrier-mediated system is widely used in the targeted delivery of drugs. Thus Staten's Seruminstitut rabbit corneal (SIRC) epithelial cell line was investigated for the expression of folate transport proteins that can be …
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