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Showing 1 to 20 of 26 for “"Folate metabolism"”.
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Folate Metabolism in the Guinea Pig
… product) were found in the urine. No radioactive folate was excreted except at very high doses when trace amounts of folic acid appeared, or after pre-treatment of the guinea pigs with antibiotics or methotrexate. Up to 20% of an oral dose of (2~14c] folic acid was found in the expired air. Only …
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Studies in the Folate Metabolism of Rats
The metabolism of 2-14C folic acid was studied in three-week-old weanling Wistar rats. Distribution of radioactivity after an oral dose of 2-14C folic acid was determined in urine, faeces, liver, and gut of the animals. Some of the urinary metabolites were characterized by column chromatography. …
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Folate Metabolism in Normal and Tumour Bearing Mammals
The whole animal metabolism and physiological disposition of folate derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative …
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Studies of Folate Metabolism in Man and the Rat
The metabolism of a mixture of [2-14C] and [3', 5', 7' ,9-3H]-folic acid was studied in man and the rat. Similar observatfons were found in both species. Folic acid is metabolised to vartous compounds. Both intact folates and folate catabolites were excreted in the urine after administration and …
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Multigenerational effects of abnormal folate metabolism on embryo growth and development
It has been known for decades that maternal folate deficiency impairs fetal development. However, the molecular mechanism of folate metabolism remains unclear. To explore this, we study a mouse model of abnormal folate metabolism whereby the gene Mtrr was mutated causing a knockdown effect. MTRR is …
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Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids
… safe treatments are sought after.<br/><br/>The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited in a number of drugs and drug targets. The same cannot be said for the kinetoplastids. Drug discovery programmes have focused on targeting enzymes …
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Investigating the Epigenetic Mechanism Behind Transgenerational Inheritance in Mice with Abnormal Folate Metabolism
… model of transgenerational inheritance in which folate metabolism is disrupted by a mutation in Methionine synthase reductase ($\it{Mtrr^gt}$). Remarkably, $\it{Mtrr^+/gt}$ heterozygosity leads to an increased likelihood of a wide spectrum of congenital malformations in their wildtype offspring …
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Methotrexat-induzierte Leukenzephalopathie bei Patienten mit akuter lymphatischer Leukämie oder lymphoblastischem Non-Hodgkin-Lymphom in Abhängigkeit vom MTHFR-C677T-Status
The antifolate Methotrexate and folate metabolism is central in therapy of pediatric Acute Lymphatic Leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate metabolism, so that combination of MTX-therapy and mutation of the MTHFR gene (MTHFR C677T) might result …
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Biochemical and Morphological Effects of Iron Deficiency And/or Chronic Ethanol Consumption During Pregnancy on the Maternal Organism and Fetal Growth and Development in Mice
… on reproductive performance as well as iron and folate metabolism. A mouse model, CBA/J strain, was employed, and morphological and biochemical assessments were performed.
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Mechanisms of epiallelic variation in mouse
… First, I deconvolute a genetic model of abnormal folate metabolism. Initial results suggest that methylation is lost at VM-IAPs in mice with altered folate metabolism. However, further assessment of the model reveals that the mutant allele also introduces a cluster of 129P2/OlaHsd mouse …
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Aspects of Folate and Tetrahydrofolate Chemistry and Metabolism in the Rat
Most of the work in the literature dealing with folate metabolism has been done using unlabelled folates, analysis being by microbiological assay. This method is not highly specific or quantitatively accurate: this thesis reports results on the synthesis of 14 c- labelled folates, and the use of …
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Genetic Association Study of Osteoporotic Vertebral Compression Fractures in Postmenopausal Women
… density, and fracture. 5, 10-Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are involved in homocysteine metabolism. Thus, we determined whether or not VEGF, MTHFR, and TS polymorphisms are associated with osteoporotic vertebral compression fractures in postmenopausal …
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Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status.
Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer risk at high fiber …
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African Trypanosome Genes Specifically Required for Fitness <i>in vivo</i>
… showed two genes linked to phosphatidylinositol metabolism, providing validation for the screen. Other hits included genes linked to folate metabolism and to DNA repair.<br/><br/>This report details the initial analysis and validation of the hits from the screen and the development of systems for …
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Folate: Friend or Foe? An investigation into the opposing roles of folate in glioma
… in glioma cells, but methylating agents such as folate, may reverse aberrant methylation. Folate treatment has shown a beneficial effect, reducing risk of certain cancers (colorectal, breast, squamous cell carcinoma) but other studies have shown detrimental results whereby proliferation of cancer …
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Coordinated regulation of glycolysis and the folate one-carbon cycle
… cell synthesize a new copy of itself, with cell metabolism supplying the building blocks for new proteins, nucleic acids and lipids. Cancer and other proliferating cell types exhibit "aerobic glycolysis" characterized by elevated glucose uptake and conversion of glucose to lactate even in the …
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Interaction between retinoids and methyl group metabolism
<p>Methyl group and folate-dependent one-carbon metabolism play in integral role in health and disease. The donation of carbon in the production of nucleic acids from folate coenzymes and the methylation of biological compounds via transmethylation metabolism is important for maintenance of cells …
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Metabolism and Handling of Folates in the Mammal Especially Man
The metabolism of oral administered folates and their handling has been studied in humans. Aseptic addition methods of microbiological assay with L.casei, S.faecalis, P.cerevisiae and bioautographic techniques were employed in investigations of serum and urine folates. Studies of normal human serum …
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Interaction of iron and folate during reproduction
… severely or moderately iron-deficient dams were folate depleted at day 17 of lactation even when maternal animals were fed twice the National Research Council's recommended amount of folate (J. Nutr. 117: 1715; J. Nutr. 113: 2471). Folate status of iron-deficient (Fe$-$) pups at day 2 were …
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Comparative whole genome transcriptional responses of Ruminococcus albus strain 7 and 8: a case for specialization and niche differentiation
… the model for fiber degradation and vitamin metabolism of the dominant fibrolytic bacteria and investigate their roles in the gut ecosystem. However, the fibrolytic mechanism and vitamin metabolism of Ruminococcus albus remain largely unknown. In the current study, comparative genomic and …
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