Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Focal Adhesion Kinase (FAK)"”.
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
… aggrecan, but not type II collagen. Furthermore, focal adhesion kinase (FAK) was found to be an upstream mediator of CCN2 expression and the absence of FAK promotes the process of chondrogenesis. Therefore, CCN2 is required for early chondrogenic events, downstream of FAK and is responsible for …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… identified as a downstream target for various kinases but effects of growth factors, which play a crucial role in the development and progression of cancer, on DLC1 have not yet been elucidated. We have identified a novel pathway involving the concerted action of Ras/Mek/Erk pathway, Focal …
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Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
… remain elusive. In this study we show that focal adhesion kinase (FAK) regulates Sox2 expression and H3K9 de-methylation through cell division control protein 42 homolog (Cdc42). In comparison to control melanoma cells, TRCs exhibit low FAK and Cdc42 expression. Overexpressing FAK or Cdc42 …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… of breast cancer. Integrin-mediated adhesion and signaling are crucial for mammary tumorigenesis and tumor progression, in which focal adhesion kinase (FAK) - Src family kinases (SFKs) serves as a hub to relay the mechanical cues from the ECM. We have investigated the mechanisms …
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
… metastasis in patients. Proteins recruited at adhesion complexes, known as the adhesome, are involved in multiple mechanisms which control cancer cell behaviour. Here, we used a proteomic and network analysis approach to perform a global assessment of functional molecular units associated with …
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LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… immunoprecipation assay, LRRK2 interacted with focal adhesion kinase (FAK), a protein that regulates the adhesion and migration of cells. LRRK2 and FAK were co-localized with ruffles when microglia actively moved. The overexpression of LRRK2 reduced the phosphorylated FAK levels compared with …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… to prevent metastatic relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and progression and describe a novel mechanism by which it facilitates immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon …
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TIS21 inhibits cell migration and invasion
… was correlated with downregulation of focal adhesion kinase (FAK) tyr576 and tyr925 residues phosphorylation. However, tyr397 which was autophosphorylation site was not influenced by TIS21 expression. c-Src phosphorylation which was upstream of FAK was not influenced by TIS21, however, …
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Computational modeling of protein-biomolecule interactions with application to mechanotransduction and antibody maturation
… a paxillin fragment bound to the FAT domain of focal adhesion kinase (FAK) revealed several structural mechanisms responsible. Second, we used computational methods to design individual mutations computed to improve binding affinity of an antibody-small molecule complex with relevance to cancer …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
… involving three repeated sequential steps: adhesion, proteolytic degradation of the basement membrane and other extracellular matrixes (ECMs), and cell migration. These three steps are linked and interdependent. For example, cell adhesion to the ECM triggers a series of signal transduction …
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
Integrins are trans-membrane receptors that form focal contacts and mediate the attachment of the smooth muscle cell cytoskeleton to the extracellular matrix. Focal adhesion kinase (FAK) regulates the recruitment and assembly of focal adhesion proteins. It has been established that integrin …
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Integrinaktivierung und Formation des "fokalen Adhäsionskomplexes" im Hypertrophieprozess adulter Mäuseherzen
… konnten wir als Zytoskelett-assoziierte Tyrosinkinasen, „focal adhesion kinase“(Fak) und c-Src, identifizieren, welche beide zum sogenannten Integrin-abhängigen fokalen Adhäsionskomplex gehören. Weitere Analysen zeigten Phosphorylierungen von Fak bei Tyr-397 und Tyr-925, c-Src bei Tyr-418. Dies …
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AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… silencing in BT-20 cell of AKR1B10 affected cell adhesion, migration and invasion, as well as metastasis to the lung in mouse models, through regulation of the expression of cell adhesion molecules (CAMs), e.g., integrin α5, δ-catenin and fibronectin. Silencing of integrin α5 and δ-catenin …
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Basal constriction : shaping the vertebrate brain
… constriction and is required for this process. Focal adhesion kinase (FAK) is activated by phosphorylation at the MHBC and is required for basal constriction. FAK activation at the MHBC is dependent upon Wnt5 function. Loss of basal constriction in Wnt5 and FAK loss-of-function embryos can be …
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Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases
… of Actg2, 15 collagen genes, and multiple focal adhesion genes. Acta2-/- SMCs showed altered localization of vinculin and zyxin and increased phosphorylated focal adhesion kinase (FAK) in focal adhesions. A specific FAK inhibitor decreased Acta2-/- SMC proliferation to levels equal to …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… multiple intracellular pathways, one of which is focal adhesion kinase (FAK). Phosphorylation of FAK can lead to the activation of various downstream signaling pathways that can increase tumor cell growth and proliferation, making it an ideal target for cancer therapeutics. Due to the fact that …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… known integrator of cell-ECM signaling, namely, focal adhesion kinase (FAK), during oligodendrocyte morphological maturation in vivo and in vitro. Conditional and inducible FAK-knockout mice (Fakflox/flox: PLP/CreERT mice) were generated to observe the effect of FAK loss on myelination in vivo. …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
<p>Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result …
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Role of DARPP-32 in Breast Cancer Cell Signalling and Migration
… potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. This thesis describes the identification of DARPP-32 as a novel interactionpartner to DDR1. We demonstrate that DARPP-32 inhibits MCF-7 cell migration and that this effect …
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Visualization of cellular signaling by fluorescence resonance energy transfer in response to biochemical and mechanical microenvironments
… a variety of cellular processes including cell adhesion and migration. While substantial progress has been made toward the understanding of how these factors regulate many cellular functions, it remains elusive on the molecular mechanism by which stem cells perceive such biochemical/mechanical …
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