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Showing 1 to 20 of 141 for “"Focal Adhesion"”.
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Structural-based Investigation of FAK and P130Cas in Focal Adhesion
… cells. The cell-ECM attachment sites are named focal adhesions (FAs), which are dynamic, large protein complexes containing more than 100 proteins. p130cas is a Src substrate localized in FAs that functions in integrin signaling to promote cell motility, invasion, proliferation and survival. The …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… known integrator of cell-ECM signaling, namely, focal adhesion kinase (FAK), during oligodendrocyte morphological maturation in vivo and in vitro. Conditional and inducible FAK-knockout mice (Fakflox/flox: PLP/CreERT mice) were generated to observe the effect of FAK loss on myelination in vivo. …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
<p>Tyrosine-phosphorylated FAK is required for the hypertrophic response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
<p>Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result …
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Integrin alpha(v) and Focal adhesion kinase - promising targets to limit smooth muscle cell migration
… Proteins, das mittels Immunpräzipitation als “focal adhesion kinase” (FAK) identifiziert wurde. Die erhöhte PTyr zeigte sich auch am Tyrosinrest FAK Tyr-397, der Autophosphorylierungsstelle der Kinase. Die erhöhte PTyr von FAK war abhängig von der Stimulation durch VN und nicht zu beobachten, …
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Force-induced calcium concentration change and focal adhesion translocation : effects of force amplitude and frequency
… including calcium signaling and activation of focal adhesion sites, but little is known about how cells initially sense changes in the external mechanical environment. In order to examine the rapid mechanosensing thresholds involved with mechanotransduction, calcium concentration changes and …
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The Roles of Focal Adhesion Assembly in Membrane Localization of Ion Channels and Action Potential Shape
… for ECM proteins that relay information to focal adhesions (FAs), force-sensitive sub-cellular structures connected to actin cytoskeleton. In different systems, dynamic changes in FA proteins as well as current flow through ion channels, including Kir2.1, are known to govern important …
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Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes
… an integrin alpha 5 blocking antibody or a focal adhesion kinase inhibitor could overcome azacitidine resistance. After establishing an effective dose of the focal adhesion kinase inhibitor, GSK2256098, I demonstrated that these doses were not toxic to healthy haematopoietic stem and …
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
Integrins are trans-membrane receptors that form focal contacts and mediate the attachment of the smooth muscle cell cytoskeleton to the extracellular matrix. Focal adhesion kinase (FAK) regulates the recruitment and assembly of focal adhesion proteins. It has been established that integrin …
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Mechanotransduction by talin : a molecular dynamics study of force-induced recruitment of vinculin to a focal adhesion complex
… Talin, an essential structural protein in the adhesion, contains the N-terminal five-helix bundle in the rod domain with a known cryptic vinculin binding site 1 (VBS1). The perturbation of this stable structure through elevated temperature or destabilizing mutation activates vinculin binding. …
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Quantitative Analysis of Integrin Trafficking and Focal Adhesion Turnover to Study Integration of Early Endocytic Trafficking, Signaling and Migration
Pages 8-153 are misnumbered as pages 9-154.
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Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations
Introduction: Cells are exposed to a wide variety of forces within the human body, and the mechanisms by which cells respond to these forces are largely unknown. From altering gene transcription in the cell nucleus to conformational changes in membrane channel proteins that lead to increased or …
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
<p>Elevated blood pressure is associated with varying degrees of arterial remodeling. The mechanisms by which extracellular mechanical stress is converted into intracellular alterations in signal transduction and gene expression have yet to be fully elucidated. Our goal was to investigate the early …
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Integrin-Linked Kinase, ECM Composition, and Substrate Rigidity Regulate Focal Adhesion - Actin Coupling, Modulating Survival, Proliferation and Migration: Towards a Biophysical Cancer Biomarker
… to sites of cell - ECM contacts known as focal adhesions. Focal adhesions (FAs) are central to cell spreading, motility, survival and growth and serve as both physical linkages between the ECM and cytoskeleton as well as signaling centers for a cell on 2D substrates. Termed focal …
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Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
… mechanisms by which fibroblasts release their adhesions to the extracellular matrix substrata using a permeabilized cell system in which the adhesions remain relatively stable. A large number of different molecules were assayed for their effect on focal adhesion stability using …
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The role of integrin mediated adhesion and signaling during Xenopus retinal development
<p>Integrins are the major family of cell adhesion receptors for extracellular matrix (ECM) components and are involved in cell-cell and cell-ECM adhesion. Integrins also participate in cytoskeletal rearrangements, activation of signal transductions, and co-regulation of growth factor …
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The mechanics of mechanotransduction : analyses of cell perturbation
… of the model to represent experimental focal adhesion attachments supported a non-uniform force transmission to basal surface focal adhesion sites. Proteins in identified zones of high stresses in the cell are candidate mechanosensors and their molecular response to force was hence …
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Investigating Mechanotransduction and Mechanosensitivity in Mammalian Cells
… to the extracellular microenvironment through focal adhesion and integrin sites. The transmission of internal actomyosin strain to the microenvironment via focal adhesion sites generates mechanical traction forces. Importantly, cells generate traction forces in response to extracellular forces …
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