Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Foamy macrophages"”.
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Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
… drug penetration into M. tuberculosis-infected macrophages. Of particular interest was the extent to which host intracellular drug concentrations translate into effective antimycobacterial activity. To this end, the thesis comprised three key aspects: (i) characterization of physicochemical …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… MEP-la, expressed both by perivascular macrophages and resident microglia, plays a role in the recruitment of inflammatory cells into CD cerebellar tissue. The highest levels of a- and ß-chemokine expression were detected in actively demyelinating MS lesions with high levels of …
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Meningeal Fibrosis in the Axolotl Spinal Cord: Extracellular Matrix and Cellular Responses
… mesenchymal ependymal cells and a population of foamy macrophages contribute to the degradation of the fibrin clot that forms in the acute phase of injury, and that this fibrin clot provides a necessary and permissive substrate for early mesenchymal outgrowth.
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
… also observed, including bronchial obstruction, foamy macrophages, lipid deposits, and cholesterol crystal formations. Human T cells (CD3+) are organized at sites of infection in the lung and liver, allowing for the study of mechanisms of immune protection and bacterial evasion. HIV/M.tb …
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Investigating iPSC-Derived Macrophage Stimulation with Oxidised Low-Density Lipoprotein as an Effective In Vitro Model of Foam Cells in Atherosclerosis
… and modification of lipoprotein particles. Macrophages and vascular smooth muscle cells (VSMCs) in the arterial wall respond by ingesting large quantities of the modified lipoproteins, such as oxidised low-density lipoproteins (oxLDLs), which are then metabolised to release cholesterol and …