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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 250 for “"Fluorophores"”.
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Benzimidazole-Based Fluorophores and Noncovalent Organic Frameworks
… core, namely L-shaped benzimidazole fluorophores. These fluorophores showed separate frontier molecular orbitals in donor–acceptor systems, similar to benzobisoxazole cruciforms. They display change in their fluorescent emission upon exposure to bases, acids and small anions. The …
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Monitoring glycation through the intrinsic fluorescence of biological fluorophores
The high blood glucose levels associated with diabetes affect various cells and proteins in the body. In response to high blood glucose the proteins collagen, keratin, and human serum albumin (HSA) experience glycation, and the cofactor reduced nicotinamide adenine dinucleotide (NADH) is also known …
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Interactions of Organic Fluorophores with Plasmonic Surface Lattice Resonances
<p>It is common knowledge that metals, alloys and pure elements alike, are lustrous and reflective, the more so when a metal surface is flat, polished, and free from oxidation and surface fouling. However, some metals reflect visible light, in the 380 nm to 740 nm range of wavelengths, much more …
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Probes of tocopherol biochemistry: fluorophores, imaging agents, and fake antioxidants
The body has many defence systems against reactive radical species, but none are as crucial in the protection of lipid membranes as vitamin E. As a result of a selection process mediated by the α-tocopherol transfer protein (α-TTP), α-tocopherol is the only form of vitamin E retained in the body. …
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Interaction of Metal Nanoparticles with Fluorophores and Their Effect on Fluorescence
… with the fluorescence emission of two fluorophores, namely eGFP and rPhiYFP; and demonstrated a bioassay where the fluorescence modulation by gold nanoparticles can be used as the sensing strategy. Lastly, we demonstrated the potential of autofluorescent gold nanoparticles as …
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Synthesis and Evaluation of New Antimicrobial Agents and Novel Organic Fluorophores
As a result of the evolution of antimicrobial resistant bacteria there is a pressing need for novel classes of antibiotics. This project aimed, in part, to design and synthesise a new family of pyrazole ligands, their zinc(II) complexes and to evaluate their antmicrobial activity. The overall goal …
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Using photo-instability to quantify fluorophores and achieve super-resolution imaging
… techniques for localizing and quantifying fluorophores in biological imaging applications. Fluorophore photobleaching, blinking, binding, etc., is exploited to quantify and localize single fluorophores, even when their fluorescent images overlap those of nearby fluorophores. In the first …
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Next-generation fluorophores for single-molecule and super-resolution fluorescence microscopy
… in the field is the development of the better fluorophores that underlie these techniques; this includes both the synthesis of new chemical derivatives and alternative novel strategies to augment existing technologies. The results of this thesis are divided into two distinct parts; Project One …
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SYNTHESIS AND DEVELOPMENT OF SILICON ANALOG OF FLUORESCEIN FLUOROPHORES AND ESTERIFICATION CATALYSTS
… developing new materials, such as fluorescence fluorophores as probes, and esterification catalysts. In the first part of the dissertation, the synthesis and characterization of a novel silicon analog of fluorescein (silyl fluorescein) was studied in detail. The photo-physical properties and …
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MODIFICATION OF XANTHENE AND SILICON ANALOGUES OF XANTHENE FLUOROPHORES FOR CHEMICAL PROBES DEVELOPMENT
… there are six major classes of small-molecular fluorophores-coumarins, boron dipyrromethene (BODIPY) dyes, fluoresceins, rhodamines, oxazines, and cyanines. This dissertation mainly focuses on modifications of fluoresceins and development of pH probes based on rhodamines. We have modified the …
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Stretching Collagen: Using Fluorophores in Collagen Mimetic Peptides as a Proposed Enantiomeric Sorting Technique
Approximately half of all therapeutic drugs sold on the market today are chiral. Chirality is the feature of a molecule whose mirror image is not superimposable. These pairs of molecules are known as enantiomers, and for medications, one enantiomer is typically biologically active for a specific …
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XANTHENE AND SILICON ANALOGS OF XANTHENE FLUOROPHORES AS CHEMICAL SENSORS FOR pH AND HYPOCHLOROUS ACID
… approach to the design of pH sensitive fluorophores has allowed for a library of compounds that are responsive over a broad range of pH (pH 3 - 10) by simply changing the substituent on the amino group. We report the synthesis and characterization of a silicon analog of rhodamine for the …
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Synthesis and Characterization of Red and Near-Infrared BODIPY-based fluorophores for various Biological Applications
… of red and NIR-emissive BODIPY-based fluorophores for various bioanalytical and biomedical applications. Chapter 1 of this dissertation represents a concise introduction to the fundamental concepts, synthetic routes, post-synthetic modification strategies and various biological …
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Cellular delivery and site-specific targeting of organic fluorophores for super-resolution imaging in living cells
… of such imaging modality is synthetic organic fluorophores with suitable brightness and photostability. However, organic fluorophores are very difficult to use in live cells because of their chemical compositions. Many excellent fluorophores, such as cyanine and Alexa Fluor dyes, are highly …
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Pyrrolo[2,3-d]pyrimidine-based π-conjugated fluorophores with 1,2,3-triazole and ethynyl linkers: synthesis and photophysical properties /
The main goal of the work was to synthesize pyrrolo[2,3-d]pyrimidine-core based oligoarylenes with ethynyl and 1,2,3-triazole linkers and to evaluate their photophysical properties. Novel chromophores - 2,4-bis(4-aryl-1,2,3-triazol-1-yl)pyrrolo[2,3-d]pyrimidines were prepared by CuAAC reaction. It …
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Developing novel SNAP tag-based antibody fusion proteins directionally conjugated to fluorophores for immunophenotyping of acute myeloid leukemia
… to a variety of synthetic labels, such as fluorophores. SNAP-tag can be coupled to scFvs (single chain variable fragments), forming unique SNAP tag antibody fusion proteins which undergo self-labelling covalent conjugation reactions with benzylguanine derivatives, and this provides an …
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Conjugated Estrogen Receptor Probes: An Evaluation of Fluorophores, Photolabile Groups, Estrogenic Ligands, and the Nature of the Attaching Chain
A good correlation exists between the level of estrogen receptor in breast tumors, and their responsiveness to hormone therapy. However, the correlation is not perfect; about 40% of women with measurable tumor receptor levels do not respond to hormone treatment. The work described herein was …
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A Description of the Electrostatic Interactions of Fluorophores With Polar Solvents Based on A Gaussian Distribution of Interaction Energies (Danca, Prodan)
… the solvent dependence of electronic spectra of fluorophores is developed which involves mainly parameters which characterize the electrostatic monopole dipole interaction.
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