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Showing 1 to 1 of 1 for “"Fluorine hydrogen bond"”.
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… of a conformationally restricting intramolecular fluorine hydrogen bond have been described. The dissertation also discusses the synthetic efforts for obtaining the pyrrolo[2,3-<em>d</em>]pyrimidine analogs with regioisomeric substitutions, modified linkers and bioisoteric replacements (general …