Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Fluorine NMR"”.
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Fluorinated amino acid derivatives
… in 75:25 ratio as determined from proton and fluorine nmr spectra. A long-range coupling was observed in fluorine nmr spectrum of 3-fluoro-2-butanone. From the ethyl 4-fluoro-3-methyl-2-pentenoate, ethyl 2-bromo-4-fluoro-3-methyl-2-pentenoate was prepared, but the latter could not be reduced …
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Structural enzymology of soluble methane monooxygenase protein-protein interactions.
… trifluoroacetone probe, allowed us to use 1D-19F-NMR to investigate the complex series of sMMO protein interactions that regulate the beginning of the sMMO catalytic cycle. A new model emerges describing how sMMO protein component affinities and exchange from protein-protein complexes control the …
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Combined Application of Density Functional Theory and Molecular Mechanics Sampling Techniques to study Chemical Systems, from Intramolecular Rearrangements to Polymerization Reactions
… of 19F chemical shifts in a library of organofluorine compounds screened for temperature sensing, and computations were used to successfully predict the chemical shift temperature sensitivity of these compounds, and finally used to guide the synthesis of more temperature sensitive compounds. …
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Fragment-based approaches to probe the surface of the VHL E3 ligase
… domain of the VHL E3 ligase was developed by fluorine nuclear magnetic resonance. Thorough characterisation of the fluorinated reporter molecules revealed features that are important for enhancing assay sensitivity. This assay has a wide detection range and was applied to both fragment …
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STUDY OF COVALENT AND NON COVALENT INTERACTIONS OF BIOPOLYMER BY MASS SPECTROMETRY
… DNA hairpin (CTGGsm) in agreement with NMR, SPR, and ITC studies. A medium throughput screening (MTS) method was setup for the screening of the fragment library (about 1,000 cps) and the procedure was validated studying the interactions between the two different DNA sequences (HFM and …
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Methods for Increasing Sensitivity and Throughput of Solid-State NMR Spectroscopy of Pharmaceutical Solids
Solid-state nuclear magnetic resonance (SSNMR) spectroscopy has been demonstrated to be a powerful technique for investigating solid dosage formulations. SSNMR has the ability to determine physical form, molecular structure, and dynamics of a pure or formulated active pharmaceutical ingredient …