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Showing 1 to 2 of 2 for “"Fluorinated Natural Product"”.
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Biosynthesis of Fluorinated Natural Product Nucleocidin
Nucleocidin is a fluorinated adenosine analogue produced by Streptomyces calvus. It is one of only six known fluorinated natural products. The 4’-fluorine substituent on nucleocidin requires a unique two-step fluorination mechanism: C-H bond cleavage followed by stereospecific glycosylation of the …
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Elucidating the Biosynthesis of Nucleocidin, a Fluorinated Natural Product Produced by Streptomyces Calvus
… produced by Streptomyces calvus, is a novel fluorinated analog of adenosine. The fluorine at the 4’-carbon of nucleocidin demands an unusual sequence of cleavage of the 4’C-H bond of the ribose ring and stereospecific glycosylation of fluoride. The nucleocidin biosynthetic gene cluster has …