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Showing 1 to 1 of 1 for “"Fluorescent/ Förster resonance energy transfer (FRET)"”.
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The intramolecular domain interactions and phosphatase activation mechanisms of Shp2
… and functions of Shp2. Here, we developed a FRET-based Shp2 reporter, a single molecule comprised of the full length human Shp2 concatenated in between a FRET pair, ECFP and YPet. In vitro incubation of Shp2 reporter with PDGFRβ induced a significant FRET increase via intramolecular …