Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 209 for “"Fluorescence imaging"”.
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Localized Excitation Fluorescence Imaging (LEFI)
… scaffolding materials, current microscope-based imaging methods cannot "see" through thick and optically opaque tissue constructs. To address this deficiency, we developed a scanning fiber imaging method capable of nondestructive imaging of fluorescently labeled cells through a thick and …
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Fluorescence Imaging for Nuclear Arms Control Verification
… treaties. Specifically, this technique uses fluorescence imaging to determine fissile material attributes in verifying, during the dismantlement process, an uncanned nuclear warhead or warhead component without revealing sensitive information. This could potentially reduce the need for an …
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Techniques and Applications of Mesoscopic Fluorescence Imaging
… in bioscience and medical research, mesoscopic imaging exchanges resolution for penetration depth, which offers hundreds of micrometer resolution and up to several millimeter penetration depth. By introducing fluorescence dyes or with intrinsic fluorescence, much higher contrast of images can be …
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Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging
… such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter-based imaging systems. Hyper and multispectral imaging facilitate the detection of both spatial and spectral information in a single data acquisition, however, instrumentation for …
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Spray combustion diagnostics with tracer-based laser-induced fluorescence imaging
Um die Vorgänge bei der Verbrennung in modernen Motorentypen, wie z.B dem direkteinspritzenden Benzinmotor, besser verstehen und optimieren zu können, haben sich in den letzten Jahren berührungsfreie, laserbasierte Diagnostik-Methoden als besonders vielseitig und hilfreich erwiesen. Die meisten …
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Fluorescence imaging microscopy studies on single molecule diffusion and photophysical dynamics
Within the last years, e.g. by investigating the fluorescence of single molecules in biological cells, remarkable progress has been made in cell biology extending conventional ensemble techniques concerning temporal / spatial resolution and the detection of particle subpopulations [82]. In addition …
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The combined AFM manipulation and fluorescence imaging of single DNA molecules
A combined fluorescence microscope/AFM set-up was constructed, which enabled the real-time manipulation of single DNA molecules. Fluorescence images of these TO-PRO-3 intercalated strands could be taken, while they were stretched with an AFM tip on silanised or polylysine covered glass surfaces. …
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Hydroxyl-Radical Planar Laser-Induced Fluorescence Imaging of Turbulent Supersonic Combustion
… hydroxyl radical (OH) planar laser-induced fluorescence (PLIF) images are presented. The OH PLIF images show instantaneous structures of turbulence in two combustor configurations at different fuel equivalence ratios in the University of Virginia Supersonic Combustion Facility (UVaSCF). …
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Techniques for high-speed high-resolution in-vivo volumetric fluorescence imaging
… high-speed, high-resolution, and quantitative imaging across complex biological samples. In the first part, we present a high-resolution multi-Z confocal microscopy system that overcomes the resolution limitations of earlier designs. By introducing a DOE to generate multiple high-NA excitation …
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Fluorescence imaging of single molecule dynamics on long single stranded DNA
Recent advances in single-molecule fluorescence imaging techniques have allowed the direct observation of protein dynamics on DNA, but the progress has been largely limited to double-stranded DNA (dsDNA) or short single-stranded DNA (ssDNA). Here, a single molecule imaging approach for observing …
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Design of an Embedded Fluorescence Imaging System for Implantable Optical Neural Recording
… understood biological system known to man. New imaging techniques are providing scientists with an entirely new perspec- tive on the study of the functional brain at a neural circuit level, enabling in-depth understanding of both physiological processes and animal models of neurological and …
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Fluorescence Imaging With One Nanometer Accuracy: Determination of How Processive Motors Walk
… with a nanometer-sized probe. We developed a new fluorescence technique that is able to locate the position of a single fluorescent dye within ∼1 nm on a glass surface. The technique of FIONA (Fluorescence Imaging with One Nanometer Accuracy) is achieved by acquiring high signal-to-noise ratio …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… Two techniques used in amyloid research are fluorescence microscopy, to map the protein location and aggregation state, and electrophysiology, to examine the effect of the proteins on neurons. To enable these techniques to be combined, a transparent graphene microelectrode array (MEA) was …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… explore the synthesis and use of antibody-based imaging agents in preclinical models of cancer. This work can be described as two-fold. In the first part, we investigated how the use of a glycans-specific bioconjugation strategy affects Fc gamma RI binding and why it results in improved <em>in …
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DNA mutation detection via fluorescence imaging in a spatial thermal gradient, capillary electrophoresis system
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
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Heterogeneity of Leaf-Level Photosynthesis as Seen Through the Lens of Ozone, Soybean, and Chlorophyll Fluorescence Imaging
… this heterogeneity. Modulated chlorophyll a fluorescence imaging (CFI) coupled with gas exchange was used to test the hypothesis that O 3 induces differential leaf-level spatial effects on photosynthesis in soybean depending on its exposure regime (acute vs. chronic). Spatial analytic …
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Design and fabrication of a precision alignment system and package for a two-photon fluorescence imaging device
A compact, lightweight precision alignment system and package for an endomicroscope was designed and fabricated. The endomicroscope will consist of a millimeter-scale fiber resonator and a two-axis silicon optical bench. The alignment system provided five degrees of freedom and was designed to …
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Synthesis, Characterizations, And Evaluation Of New Reactive Two-photon Absorbing Dyes For Two-photon Excited Fluorescence Imaging Applications
… for the development and application of the novel imaging modality utilizing multiphoton absorption and its extraordinary contribution to recent advances in bioimaging. Intimately involved in the revolution of nonlinear bioimaging has been the development of optical probes for probing biological …
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Development and validation of a theoretical model for optimizing signal-to-noise ratio in x-ray fluorescence imaging
… has been a growing interest in benchtop X-ray Fluorescence Computed Tomography (XFCT) due to its potential to non-invasively image non-radioactive targets at greater depths than optical techniques. However, this modality suffers from limited sensitivity due to the high scattering background and …
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Synthesis of Fluorene-based derivatives, Characterization of Optical properties and their Applications in Two-photon Fluorescence Imaging and Photocatalysis
… have been used are three-dimensional (3D) fluorescence imaging and optical power limiting. Two-photon absorbing materials are, therefore, in great demand to meet the needs of emerging technologies. Organic molecules show great promise to meet this need as they can be customized through …
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