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Showing 1 to 10 of 10 for “"Flunixin Meglumine"”.
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Inflammation, Phagocytosis and Effect of Flunixin Meglumine During Endotoxin-Induced Mastitis (Therapy, Prostaglandins)
… (PGF(,2(alpha))); (2) the pharmacokinetics of flunixin meglumine in lactating cattle; (3) the clinical efficacy of the flunixin meglumine and its effect on milk and plasma TXB(,2) and PGF(,2(alpha)); and (4) changes of whey immunoglobulins and ability of wheys to enhance neutrophil phagocytosis …
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Effects of systemic flunixin meglumine, topical oxytetracycline, and topical prednisolone acetate on tear film proteinases innormal horses
… topical prednisolone acetate, and systemic flunixin meglumine, on the activity of two proteinases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), in equine tear film. The study design consisted of twelve ophthalmically normal horses separated into three groups of …
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The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function
… the effect of three NSAIDs in the horse. Flunixin meglumine is commonly used to treat pain and endotoxemia associated with colic in the horse. Deracoxib and firocoxib have been shown to be COX-2 selective in the dog. This study used in vitro whole blood assays to determine the effect of …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
… abilities of doxycycline, oxytetracycline, and flunixin meglumine to inhibit LPS-induced equine MMP-2 and MMP-9 activities in vitro were investigated using a digital laminar explant model. The structural integrity of the explants was tested using an Instron biomechanical testing device, and MMP …
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Effect Of A Cidr Insert And Flunixin Meglumine Administered At The Time Of Embryo Transfer On Pregnancy Rate And Resynchronization Of Estrus In Beef Cattle
… of this study were to evaluate the effects of flunixin meglumine (FM), an inhibitor of PGF2a synthesis, administered at the time of embryo transfer (ET) and insertion of an intravaginal progesterone-releasing device (CIDR) at the time of ET on pregnancy rates (PR) and the resynchronization of …
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Applications of Physiologically Based Pharmacokinetic Models in Veterinary Medicine.
… binding interactions between sulfamethazine and flunixin meglumine. Flunixin meglumine has recently been approved for use in swine. Thus there is an increased likelihood that a drug interaction could be seen in swine. To explore this possibility, a PBPK model for sulfamethazine was designed that …
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The Effect of Prostaglandin Inhibitor on Pregnancy Rates of Heifer Embryo Transfer Recipients
… administration of the prostaglandin inhibitor, flunixin meglumine, immediately prior to embryo transfer increases pregnancy rates in heifers. Heifers (n=466) were divided into two equal groups based on BCS (range=6-7) and weight (range=256-455). Estrus was synchronized in heifers by giving two …
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The Clinical Pharmacology of Acetaminophen in Adult Horses
… cyclooxygenase (COX) inhibitors, such as flunixin meglumine and phenylbutazone, which act through global inhibition of prostaglandin synthesis and release. While non-selective COX inhibitors are effective as anti-inflammatory agents, they are mired with complications with prolonged or …
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The use of activity measures in combination with physiological factors as indicators of disease in dairy cattle
… An initial study determined the impact of flunixin meglumine (FM), a non-steroidal anti-inflammatory drug, on activity measures, dry matter intake (DMI) and milk production during experimentally induced Escherichia coli mastitis. A total of 24 primiparous and multiparous lactating dairy …
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Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
… a total of 42 different drugs and metabolites. Flunixin was the second most commonly identified drug. Currently no nonsteroidal anti-inflammatory drugs (NSAIDs) are approved by the Food and Drug Administration (FDA) for small ruminants, but drugs such as flunixin and meloxicam are used in small …