Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Fluid percussion"”.
-
Iterative learning control for improved tracking of fluid percussion injury device
… on the head during such TBI events. Lateral Fluid Percussion (FPI) brain injury is one of the most commonly used and well-characterized experimental models of TBI. A Fluid Percussion Injury (FPI) device in the laboratory is used to replicate the injury but does not execute the desired …
-
The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats
In addition to the acute pathology produced by traumatic brain injury, there are chronic alterations that occur after the trauma, including a depressed state of neuronal activity (Feeney, 1991). This study included a preclinical testing of a novel treatment strategy focusing on increasing neuronal …
-
The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… combine model of prolonged hemorrhagic shock and fluid percussion injury. Our studies showed that the selective inhibitor, AG, maybe beneficial as a potentially useful therapeutic agent in our model of prolonged hemorrhagic shock and the combine model of prolonged hemorrhagic shock and fluid …
-
Modeling subconcussive and cumulative subconcussive impacts using a lateral fluid percusion injury device
… scientific community. This study used a lateral fluid percussion injury (lFPI) to model a subconcussive insult; specifically, to test the hypothesis that an initial subconcussive insult will not lead to any significant detectable levels of behavioral or cellular damage, yet cumulative intra-day …
-
Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury
… neuronal damage is a key feature of experimental fluid percussion traumatic brain injury in rodents. However, the mechanisms contributing to the susceptibility to neuronal injury in this region are largely unknown. Since free ionic zinc (Zn2+) was shown to be toxic to neurons in vitro, I sought to …
-
Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
… Sprague-Dawley rats that underwent a lateral fluid percussion injury (FPI) at acute (2 and 7 days post-injury), intermediate (28 days post-injury), and chronic (3 months post-injury) time-points to investigate whether decreased insulin responsiveness in TBI animals is playing a role in …
-
Traumatic Brain Injury Accelerates Alzheimer’s Disease Pathology in the TgF344-AD Rat Model
… old) were randomized to receive parasagittal fluid percussion injury, sham injury, or naïve (N=10-16 rats/group). Neurobehavioral tests (beam walk, beam balance, neuroscore) were performed on post-injury days 1-3 and 3 months after injury. Water maze test was performed 3 months after Injury, …
-
FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
… TBI. Our results demonstrate that mild lateral fluid percussion injury (LFPI) significantly impairs fear extinction memory, as evidenced by an elevated cued-fear response during extinction testing 10 days post-injury. Field potential recordings revealed decreased activation of the IL network in …
-
Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
… was not model-specific, we examined a moderate fluid-percussion model of brain injury. Calcineurin activity was significantly increased in hippocampal and cortical homogenates. This increased activity persisted for several weeks post-injury, and may be involved in injury-induced neuronal …
-
Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… In an in vivo model of neural injury, namely fluid percussion TBI of rats, changes of [Zn2+]i were indirectly demonstrated by measuring the levels and states of the zinc-binding protein, metallothionein/thionein, in the hippocampus and the cortex. These results demonstrate that [Zn2+]i as well …
-
Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
… in rats using a well-established model of TBI, fluid percussion injury (FPI). Rats were sacrificed, and tissue harvested at various post-injury intervals (4 TBI, 4 Sham control at 24hr, 2 wk, 1, 2, 3, 6, and 12-month post-TBI, n= 56). Using a bioinformatic platform (Ingenuity Pathway Analysis), …
-
Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… UEC) and the other maladaptive plasticity (fluid percussion injury + bilateral EC lesions; TBI+BEC), targeting 2, 7, and 15d postinjury intervals. In adaptive UEC plasticity, membrane-bound MMP expression was elevated during synaptic degeneration (2d) and regeneration (7d), and normalized at …
-
Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… in the hippocampus of rats subjected to fluid percussion injury (FPI). I found that a single five minutes transcranial application of NPLT, one hour after FPI, significantly increased neuronal differentiation of DCX+ neuronal progenitor cells in the SGZ and reduced their aberrant …
-
Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… in the hippocampus of rats subjected to fluid percussion injury (FPI). I found that a single five minutes transcranial application of NPLT, one hour after FPI, significantly increased neuronal differentiation of DCX+ neuronal progenitor cells in the SGZ and reduced their aberrant …
-
Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
… brain and lung following TBI using the lateral fluid percussion injury (FPI) in an in-vivo murine model. In the murine FPI model, alongside cerebral inflammation (associated with neuronal damage and the infiltration of inflammatory cells), there is significant neutrophil accumulation within the …
-
Monitoring of cerebellar injury using micro ECoG signals in ketamine/xylazine treated rats
… the injury progression in a rat model of fluid percussion injury (FPI). A mechanical tap on the dorsal hand was used as a stimulus, and EPs were recorded from the paramedian lobule (PML) of the posterior cerebellum via multi-electrode arrays (MEA). Evoked response amplitudes (EPAs) were …
-
Investigation of chemokine expression and modulation following traumatic brain injury
… expression in-vivo I established the rat lateral fluid percussion injury (LFPI) model of TBI and measured MIP-2/CXCL2 and MCP-1/CCL2 expression in the brain following injury. Inhibition of this expression by dexamethasone and FK506 was then investigated. To identify the cellular source of …
-
Rate alterable traumatic brain injury device for rodent models
Traumatic Brain Injury (TBI) is a physical impact to the head resulting in functional deficits in memory and motor systems. TBI is a prevalent problem occurring in 1.7 million people annually in the United States (Faul et al. 2010). TBIs can differ greatly in terms of the biomechanics of the impact …
-
Spatial light interference microscopy (slim) measurements of hypothermia in an experimental cellular model of traumatic brain injury
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms